Early exposure to distinct sources of lipids affects differently the development and hepatic inflammatory profiles of 21-day-old rat offspring

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dc.citation.volume11
dc.contributor.authorMennitti, Lais Vales [UNIFESP]
dc.contributor.authorOyama, Lila Missae [UNIFESP]
dc.contributor.authorSantamarina, Aline Boveto [UNIFESP]
dc.contributor.authorda Penha Oller do Nascimento, Claudia Maria [UNIFESP]
dc.contributor.authorPisani, Luciana Pellegrini [UNIFESP]
dc.coverageAlbany
dc.date.accessioned2020-07-02T18:52:10Z
dc.date.available2020-07-02T18:52:10Z
dc.date.issued2018
dc.description.abstractIntroduction: Maternal diet composition of fatty acids during pregnancy and lactation seems to modify the fetal programming, epigenetic pattern and offspring phenotype. Aim: Herein, we investigated the effects of maternal consumption of normal-fat diets with distinct lipid sources during pregnancy and lactation on the somatic development and proinflammatory status of 21-day-old rat offspring. Materials and Methods: On the first day of pregnancy, female Wistar rats were divided into four groups as follows: soybean oil (M-SO), lard (M-L), hydrogenated vegetable fat (M-HVF) and fish oil (M-FO). Diets were maintained during pregnancy and lactation. Male offspring constituted the SO, L, HVF and FO groups. Pups were weighed and measured weekly. Lipopolysaccharide serum concentration was determined. Tumor necrosis factor alpha, interleukin (IL)-6 and IL-10 in the liver were evaluated by enzyme-linked immunosorbent assay. Liver gene expressions were determined by real-time polymerase chain reaction. Protein expressions in the liver were analyzed by Western blotting. Results: We observed an increase in body weight and adiposity in L and HVF groups. Moreover, HVF group showed an increase in the toll-like receptor 4 mRNA levels, IL10R alpha and phosphorylated form of I kappa B kinase (IKKp-IKK alpha+beta) protein expression. The FO group presented a decrease in body weight, relative weight of retroperitoneal adipose tissue, ADIPOR2 gene expression, lipopolysaccharide and p-IKK alpha+beta and phosphorylated form of nuclear transcription factor kappa B (NF kappa B) p50 (p-NF kappa B p50) protein expression. Conclusion: Summarily, whereas maternal intake of normal-fat diets based on L and HVF appear to affect the somatic development negatively, only early exposure to HVF impairs the pups' proinflammatory status. In contrast, maternal diets based on FO during pregnancy and lactation have been more beneficial to the adiposity and toll-like receptor 4 signaling pathway of the 21-day-old rat offspring, particularly when compared to L or HVF diets.en
dc.description.affiliationFed Univ Sao Paulo UNIFESP, PhD Program Interdisciplinar Hlth Sci, Santos, SP, Brazil
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Discipline Nutr Physiol, Dept Physiol, Sao Paulo, SP, Brazil
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Inst Hlth & Soc, Dept Biosci, Santos, SP, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, PhD Program Interdisciplinar Hlth Sci, Santos, SP, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Discipline Nutr Physiol, Dept Physiol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Inst Hlth & Soc, Dept Biosci, Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2014/10683-0
dc.format.extent11-23
dc.identifierhttp://dx.doi.org/10.2147/JIR.S152326
dc.identifier.citationJournal Of Inflammation Research. Albany, v. 11, p. 11-23, 2018.
dc.identifier.doi10.2147/JIR.S152326
dc.identifier.fileWOS000422670100002.pdf
dc.identifier.issn1178-7031
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53920
dc.identifier.wosWOS:000422670100002
dc.language.isoeng
dc.publisherDove Medical Press Ltd
dc.relation.ispartofJournal Of Inflammation Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectfatty acidsen
dc.subjectpregnancy and lactationen
dc.subjectadiposityen
dc.subjectproinflammatory statusen
dc.subjectpupsen
dc.titleEarly exposure to distinct sources of lipids affects differently the development and hepatic inflammatory profiles of 21-day-old rat offspringen
dc.typeinfo:eu-repo/semantics/article
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