Hormone profile in juvenile systemic lupus erythematosus with previous or current amenorrhea

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dc.contributor.authorSilva, Clovis A.
dc.contributor.authorDeen, Maria E. J.
dc.contributor.authorFebronio, Marilia V.
dc.contributor.authorOliveira, Sheila K.
dc.contributor.authorTerreri, Maria T. [UNIFESP]
dc.contributor.authorSacchetti, Silvana B.
dc.contributor.authorSztajnbok, Flavio R.
dc.contributor.authorMarini, Roberto
dc.contributor.authorQuintero, Maria V.
dc.contributor.authorBica, Blanca E.
dc.contributor.authorPereira, Rosa M.
dc.contributor.authorBonfa, Eloisa
dc.contributor.authorFerriani, Virginia P.
dc.contributor.authorRobazzi, Teresa C.
dc.contributor.authorMagalhaes, Claudia S.
dc.contributor.authorHilario, Maria O. [UNIFESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionRijks Univ Groningen
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Estadual Rio Janeiro
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionPediat Rheumatol Unit
dc.contributor.institutionHosp Sao Rafael
dc.date.accessioned2016-01-24T14:17:02Z
dc.date.available2016-01-24T14:17:02Z
dc.date.issued2011-08-01
dc.description.abstractTo identify the underlying mechanism of amenorrhea in juvenile systemic lupus erythematosus (JSLE) patients, thirty-five (11.7%) JSLE patients with current or previous amenorrhea were consecutively selected among the 298 post-menarche patients followed in 12 Brazilian pediatric rheumatology centers. Pituitary gonadotrophins [follicle-stimulating hormone (FSH) and luteinizing hormone (LH)] and estradiol were evaluated in 32/35 patients, and prolactin and total testosterone in 29/35 patients. Patient's medical records were carefully reviewed according to demographic, clinical and therapeutic findings. the mean duration of amenorrhea was 7.2 +/- A 3.6 months. Low FSH or LH was observed in 7/32 (22%) JSLE patients and normal FSH or LH in 25 (78%). Remarkably, low levels of FSH or LH were associated with higher frequency of current amenorrhea (57% vs. 0%, P = 0.001), higher median disease activity (SLEDAI) and damage (SLICC/ACR-DI) (18 vs. 4, P = 0.011; 2 vs. 0, P = 0.037, respectively) and higher median current dose of prednisone (60 vs. 10 mg/day, P = 0.0001) compared to normal FSH or LH JSLE patients. None of them had decreased ovarian reserve and premature ovarian failure. Six of 29 (21%) patients had high levels of prolactin, and none had current amenorrhea. No correlations were observed between levels of prolactin and SLEDAI, and levels of prolactin and SLICC/ACR-DI scores (Spearman's coefficient). We have identified that amenorrhea in JSLE is associated with high dose of corticosteroids indicated for active disease due to hypothalamic-pituitary-ovary axis suppression.en
dc.description.affiliationUniv São Paulo, Fac Med, Pediat Rheumatol Unit, Inst Crianca, BR-05442010 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Med, Div Rheumatol, BR-05442010 São Paulo, Brazil
dc.description.affiliationRijks Univ Groningen, Groningen, Netherlands
dc.description.affiliationUniv Fed Rio de Janeiro, Pediat Rheumatol Unit, Rio de Janeiro, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Pediat Rheumatol Serv, São Paulo, Brazil
dc.description.affiliationUniv Estadual Rio Janeiro, Pediat Rheumatol Unit, Rio de Janeiro, Brazil
dc.description.affiliationUniv Estadual Campinas, Pediat Rheumatol Unit, Campinas, SP, Brazil
dc.description.affiliationPediat Rheumatol Unit, Belo Horizonte, RJ, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, Div Rheumatol, Rio de Janeiro, Brazil
dc.description.affiliationUniv São Paulo, Pediat Rheumatol Unit, BR-14049 Ribeirao Preto, SP, Brazil
dc.description.affiliationHosp Sao Rafael, Pediat Rheumatol Unit, Salvador, BA, Brazil
dc.description.affiliationUniv Estadual Paulista, Pediat Rheumatol Unit, Botucatu, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Pediat Rheumatol Unit, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Pediat Rheumatol Serv, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Pediat Rheumatol Unit, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFederico Foundation
dc.description.sponsorshipIDCNPq: 300248/2008-3
dc.description.sponsorshipIDCNPq: 305468/2006-5
dc.description.sponsorshipIDCNPq: 301487/2007-3
dc.format.extent1037-1043
dc.identifierhttp://dx.doi.org/10.1007/s00296-010-1389-2
dc.identifier.citationRheumatology International. Heidelberg: Springer Heidelberg, v. 31, n. 8, p. 1037-1043, 2011.
dc.identifier.doi10.1007/s00296-010-1389-2
dc.identifier.issn0172-8172
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33910
dc.identifier.wosWOS:000293024300008
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofRheumatology International
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectJuvenile systemic lupus erythematosusen
dc.subjectAdolescenten
dc.subjectAmenorrheaen
dc.subjectGonadal functionen
dc.subjectHormoneen
dc.subjectPrednisoneen
dc.titleHormone profile in juvenile systemic lupus erythematosus with previous or current amenorrheaen
dc.typeinfo:eu-repo/semantics/article
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