Functional magnetic resonance imaging response as an early biomarker of cognitive decline in elderly patients with metabolic syndrome

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dc.citation.volume73
dc.contributor.authorShigaeff, Nadia [UNIFESP]
dc.contributor.authorAmaro, Edson
dc.contributor.authorFranco, Fabio G. M.
dc.contributor.authorJacinto, Alessandro F. [UNIFESP]
dc.contributor.authorChiochetta, Gabriela [UNIFESP]
dc.contributor.authorCendoroglo, Maysa S. [UNIFESP]
dc.contributor.authorCitero, Vanessa A. [UNIFESP]
dc.coverageClare
dc.date.accessioned2020-09-01T13:21:28Z
dc.date.available2020-09-01T13:21:28Z
dc.date.issued2017
dc.description.abstractObjectives: We assessed whether potential changes in brain activation patterns of elderly individuals with metabolic syndrome (MetS) who were cognitively healthy (without mild cognitive impairment or dementia) were associated with cognitive decline in executive function in the short-term. Method: We analyzed 43 individuals (23 MetS, 20 controls) using a global geriatric evaluation, a neuropsychological battery, and task-related (attention) fMRI exam. Correlation analysis between the fMRI signal at baseline and cognitive impairment after 1 year was based on the voxel-based Pearson coefficient, corrected for multiple comparisons. Results: At baseline, MetS patients showed reduced brain response in frontal and parietal regions compared to controls. After one year, the MetS group also showed a decline in verbal fluency performance. fMRI response in the right dorsolateral prefrontal cortex and bilateral parietal lobes was negatively correlated with verbal fluency decline in the MetS group. Discussion: Our results provide an early biomarker of the possible development of cognitive impairment, particularly in the executive function, of elderly individuals suffering from MetS. These findings also point to an up or down regulation which could be interpreted as compensatory mechanism for possible brain tissue burden caused by MetS.en
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Psychiat, Rua Borges Lagoa 570, BR-04038030 Sao Paulo, SP, Brazil
dc.description.affiliationHosp Israelita Albert Einstein, Rua Borges Lagoa 570, BR-04038030 Sao Paulo, SP, Brazil
dc.description.affiliationHosp Israelita Albert Einstein, Ave Albert Einstein, Sao Paulo, Brazil
dc.description.affiliationHosp Israelita Albert Einstein, Rua Madre Cabrini 462, BR-04020001 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Estadual Sao Paulo Julio de Mesquita Filho, Fac Med Botucatu, Dept Internal Med, Rua Borges Lagoa 570, BR-04038030 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Internal Med, Div Geriatr, Rua Francisco de Castro 105, BR-04020050 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Dept Psychiat, Rua Borges Lagoa 570, BR-04038030 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Dept Internal Med, Div Geriatr, Rua Francisco de Castro 105, BR-04020050 Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.description.sponsorshipMinistry of Health which, via Technical Area of Health of Aged (PROADI)
dc.description.sponsorshipHospital Israelita Albert Einstein under Support Program for Institutional Development of Brazilian Unified National Health System (SUS)
dc.description.sponsorshipIDCAPES: 2009/12271-3
dc.format.extent1-7
dc.identifierhttp://dx.doi.org/10.1016/j.archger.2017.07.002
dc.identifier.citationArchives Of Gerontology And Geriatrics. Clare, v. 73, p. 1-7, 2017.
dc.identifier.doi10.1016/j.archger.2017.07.002
dc.identifier.issn0167-4943
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58283
dc.identifier.wosWOS:000413123600001
dc.language.isoeng
dc.publisherElsevier Ireland Ltd
dc.relation.ispartofArchives Of Gerontology And Geriatrics
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectMetabolic syndromeen
dc.subjectElderlyen
dc.subjectBiomarkeren
dc.subjectNeuropsychological assessmenten
dc.subjectCognitive impairmenten
dc.subjectFunctional magnetic resonanceen
dc.titleFunctional magnetic resonance imaging response as an early biomarker of cognitive decline in elderly patients with metabolic syndromeen
dc.typeinfo:eu-repo/semantics/article
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