Effects of progesterone on sleep: A possible pharmacological treatment for sleep-breathing disorders?

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dc.contributor.authorAndersen, Monica Levy [UNIFESP]
dc.contributor.authorBittencourt, Lia Rita Azeredo [UNIFESP]
dc.contributor.authorAntunes, I. B.
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:40:54Z
dc.date.available2016-01-24T12:40:54Z
dc.date.issued2006-01-01
dc.description.abstractProgesterone is present in a wide spectrum of biological activity within a variety of tissues. This hormone is also known to affect reproduction, sleep quality, respiration, mood, appetite, learning, memory and sexual activity. Progesterone exerts a sleep induction or hypnotic effect and is a potent respiratory stimulant that has been associated to a decrease in the number of central and obstructive sleep apnea episodes in men. the literature also contains a substantial amount of data on the effect of apnea in women with obesity-hypoventilation during menopause. This review attempts to outline the specific role of progesterone in normal sleep and breathing as well as its possible therapeutic effects in the treatment of sleep-disordered breathing.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, EPM, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, EPM, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent3575-3582
dc.identifierhttp://dx.doi.org/10.2174/092986706779026200
dc.identifier.citationCurrent Medicinal Chemistry. Sharjah: Bentham Science Publ Ltd, v. 13, n. 29, p. 3575-3582, 2006.
dc.identifier.doi10.2174/092986706779026200
dc.identifier.issn0929-8673
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/28686
dc.identifier.wosWOS:000242002600007
dc.language.isoeng
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Medicinal Chemistry
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectprogesteroneen
dc.subjectsleepen
dc.subjectsleep apneaen
dc.subjectbreathingen
dc.subjecthormonal controlen
dc.titleEffects of progesterone on sleep: A possible pharmacological treatment for sleep-breathing disorders?en
dc.typeinfo:eu-repo/semantics/article
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