Perinatal factors associated with early neonatal deaths in very low birth weight preterm infants in Northeast Brazil

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dc.contributor.authorCastro, Eveline Campos Monteiro de
dc.contributor.authorLeite, Alvaro Jorge Madeiro
dc.contributor.authorAlmeida, Maria Fernanda Branco de [UNIFESP]
dc.contributor.authorGuinsburg, Ruth [UNIFESP]
dc.contributor.institutionUniv Fed Ceara
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:38:19Z
dc.date.available2016-01-24T14:38:19Z
dc.date.issued2014-12-20
dc.description.abstractBackground: in Brazil, the prevalence of prematurity has increased in recent years and it is a major cause of death in the neonatal period. Therefore, this study aims at assessing perinatal factors associated with early neonatal deaths in very low birth weight preterm infants born in a region of Brazil with low Human Development Index.Methods: Prospective cohort study of inborns with gestational age 23(0/7)-31(6/7) weeks and birthweight 500-1499 g without malformations in 19 public reference hospitals of the state capitals of Brazil's Northeast Region. Perinatal variables associated with early neonatal death were determined by Cox regression analysis.Result: Among 627 neonates, 179 (29%) died with 0-6 days after birth. Early death was associated to: absence of antenatal steroids (HR 1.59; 95% CI 1.11-2.27), multiple gestation (1.95; 1.28-3.00), male sex (2.01; 1.40-2.86), 5th minute Apgar <7 (2.93; 2.03-4.21), birthweight <1000 g (2.58; 1.70-3.88), gestational age <28 weeks (2.07; 1.42-3.02), use of surfactant (1.65; 1.04-2.59), and non-use of a pain scale (1.89; 1.24-2.89).Conclusion: Biological variables and factors related to the quality of perinatal care were associated with the high chance of early death of preterm infants born in reference hospitals of Northeast Brazil.en
dc.description.affiliationUniv Fed Ceara, Maternidade Escola Assis Chateaubriand, Neonatal Unit, BR-60165121 Fortaleza, Ceara, Brazil
dc.description.affiliationUniv Fed Ceara, Dept Maternal & Child Hlth, BR-60165121 Fortaleza, Ceara, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pediat, Escola Paulista Med, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pediat, Escola Paulista Med, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipBrazilian Ministry of Health
dc.format.extent8
dc.identifierhttp://dx.doi.org/10.1186/s12887-014-0312-5
dc.identifier.citationBmc Pediatrics. London: Biomed Central Ltd, v. 14, 8 p., 2014.
dc.identifier.doi10.1186/s12887-014-0312-5
dc.identifier.fileWOS000349047500001.pdf
dc.identifier.issn1471-2431
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38561
dc.identifier.wosWOS:000349047500001
dc.language.isoeng
dc.publisherBiomed Central Ltd
dc.relation.ispartofBmc Pediatrics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPremature newborn infanten
dc.subjectVery low weight newborn infanten
dc.subjectNeonatal mortalityen
dc.subjectEarly neonatal mortalityen
dc.subjectNeonatal ICUen
dc.titlePerinatal factors associated with early neonatal deaths in very low birth weight preterm infants in Northeast Brazilen
dc.typeinfo:eu-repo/semantics/article
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