Angiogenesis and skin carcinomas with skull base invasion: A case-control study

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dc.contributor.authorCernea, C. R.
dc.contributor.authorFerraz, A. R.
dc.contributor.authorCastro, IV de
dc.contributor.authorSotto, M. N.
dc.contributor.authorLogullo, A. F.
dc.contributor.authorBacchi, C. E.
dc.contributor.authorPotenza, A. S.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:37:07Z
dc.date.available2016-01-24T12:37:07Z
dc.date.issued2004-05-01
dc.description.abstractBackground. Some skin carcinomas may be very aggressive. Intensity of angiogenesis, measured by intratumoral vessel density using expression of CD34, has been associated with tumor aggressiveness. in this study, the expression of CD34 in basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) with skull base invasion was compared with that in tumors with good outcome.Methods. Expression of CD34 was graded as mild, moderate, and intense, in 24 BCCs and 11 SCCs with skull base invasion. the control group included 23 BCCs and 10 SCCs.Results. Intense expression of CD34 was noted in 25.00% of BCCs with skull base invasion, compared with 4.35% in the control group (p =.058). Regarding SCCs, intense expression of CD34 was found in 54.55% of aggressive tumors, compared with 10.00% in the control group (p = 133).Conclusions. A trend toward denser microvascular angiogenesis was observed in both BCCs and SCCs with skull base invasion compared with less aggressive controls. (C) 2004 Wiley Periodicals, Inc.en
dc.description.affiliationUniv São Paulo, Sch Med, Dept Head & Neck Surg, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Sch Med, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, Dept Pathol, Botucatu, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent396-400
dc.identifierhttp://dx.doi.org/10.1002/hed.10399
dc.identifier.citationHead and Neck-Journal for the Sciences and Specialties of the Head and Neck. Hoboken: John Wiley & Sons Inc, v. 26, n. 5, p. 396-400, 2004.
dc.identifier.doi10.1002/hed.10399
dc.identifier.issn1043-3074
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/27722
dc.identifier.wosWOS:000221236600002
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofHead and Neck-Journal for the Sciences and Specialties of the Head and Neck
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectangiogenesisen
dc.subjectbasal cell carcinomaen
dc.subjectsquamous cell carcinomaen
dc.subjectbase of skullen
dc.subjectimmunohistochemistryen
dc.titleAngiogenesis and skin carcinomas with skull base invasion: A case-control studyen
dc.typeinfo:eu-repo/semantics/article
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