LONG-TERM TREATMENT WITH STANDARDIZED EXTRACT of GINKGO BILOBA L. ENHANCES the CONDITIONED SUPPRESSION of LICKING in RATS BY the MODULATION of NEURONAL and GLIAL CELL FUNCTION in the DORSAL HIPPOCAMPUS and CENTRAL AMYGDALA

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dc.contributor.authorOliveira, D. R. [UNIFESP]
dc.contributor.authorSanada, P. F. [UNIFESP]
dc.contributor.authorFilho, A. C. S. [UNIFESP]
dc.contributor.authorConceicao, G. M. S. [UNIFESP]
dc.contributor.authorCerutti, J. M. [UNIFESP]
dc.contributor.authorCerutti, S. M. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:31:34Z
dc.date.available2016-01-24T14:31:34Z
dc.date.issued2013-04-03
dc.description.abstractOur group previously demonstrated that short-term treatment with a standardized extract of Ginkgo biloba (EGb) changed fear-conditioned memory by modulating gene expression in the hippocampus, amygdaloid complex and prefrontal cortex. Although there are few controlled studies that support the long-term use of EGb for the prevention and/or treatment of memory impairment, the chronic use of Ginkgo is common. This study evaluated the effects of chronic treatment with EGb on the conditioned emotional response, assessed by the suppression of ongoing behavior and in the modulation of gene and protein expression. Male adult Wistar rats were treated over 28 days and assigned to five groups (n = 10) as follows: positive control (4 mg kg(-1) Diazepam), negative control (12% Tween 80), EGb groups (0.5 and 1.0 g kg(-1)) and the naive group. the suppression of the licking response was calculated for each rat in six trials. Our results provide further evidence for the efficacy of EGb on memory. for the first time, we show that long-term treatment with the highest dose of EGb improves the fear memory and suggests that increased cAMP-responsive element-binding protein (CREB)-1 and glial fibrillary acidic protein (GFAP) mRNA and protein (P < 0.001) in the dorsal hippocampus and amygdaloid complex and reduced growth and plasticity-associated protein 43 (GAP-43) (P < 0.01) in the hippocampus are involved in this process. the fear memory/treatment-dependent changes observed in our study suggest that EGb might be effective for memory enhancement through its effect on the dorsal hippocampus and amygdaloid complex. (C) 2013 Published by Elsevier B.V. on behalf of IBRO.en
dc.description.affiliationUniversidade Federal de São Paulo, Behav Pharmacol & Etnopharmacol Lab, Dept Biol Sci, São Paulo, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Genet Bases Thyroid Tumor Lab, Div Genet, Dept Morphol & Genet, São Paulo, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biol Sci, São Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Behav Pharmacol & Etnopharmacol Lab, Dept Biol Sci, São Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Genet Bases Thyroid Tumor Lab, Div Genet, Dept Morphol & Genet, São Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biol Sci, São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIDFAPESP: 02-09457-9
dc.description.sponsorshipIDCAPES: 05-60330-8
dc.format.extent70-86
dc.identifierhttp://dx.doi.org/10.1016/j.neuroscience.2013.01.009
dc.identifier.citationNeuroscience. Oxford: Pergamon-Elsevier B.V., v. 235, p. 70-86, 2013.
dc.identifier.doi10.1016/j.neuroscience.2013.01.009
dc.identifier.issn0306-4522
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36196
dc.identifier.wosWOS:000316973800008
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNeuroscience
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectGinkgo bilobaen
dc.subjectconditioned suppressionen
dc.subjectdorsal hippocampusen
dc.subjectamygdalaen
dc.subjectCREB-1en
dc.subjectGFAPen
dc.titleLONG-TERM TREATMENT WITH STANDARDIZED EXTRACT of GINKGO BILOBA L. ENHANCES the CONDITIONED SUPPRESSION of LICKING in RATS BY the MODULATION of NEURONAL and GLIAL CELL FUNCTION in the DORSAL HIPPOCAMPUS and CENTRAL AMYGDALAen
dc.typeinfo:eu-repo/semantics/article
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