Transcutaneous electrical nerve stimulation in viability of a random skin flap in nicotine-treated rats

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dc.contributor.authorAbrantes Russo, Claudia Regina
dc.contributor.authorLeite, Mauro Teixeira
dc.contributor.authorGomes, Heitor Carvalho
dc.contributor.authorFerreira, Lydia Masako
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:41:39Z
dc.date.available2016-01-24T12:41:39Z
dc.date.issued2006-12-01
dc.description.abstractBackground: Skin flaps are extensively used in plastic surgery, the main postoperative problems being ischemia and necrosis. Nicotine has acute vasoconstrictive properties, diminishing blood flow and increasing the risk of flap necrosis. Transcutaneous electrical nerve stimulation (TENS) was effective in reducing necrosis in random skin flaps in rats. Therefore, the authors decided to test the efficacy of TENS to reduce necrosis in the presence of nicotine.Methods: Sixteen adult male Wistar-Escola Paulista de Medicina (EPM) rats were distributed, at random, in 2 groups of 8 animals. the nicotine group (NG) received this drug subcutaneously (1.2 mg/kg/d), for 1 week before flap elevation. the nicotine plus TENS group (NTG) followed the same routine. Immediately after the operative procedure and on the next 2 postoperative days, the treatment group (NTG) was submitted to TENS during an hour under anesthesia. NG animals were sham exposed. After 7 days, the percentages of necrosis were determined.Results: the NG had a mean value of 45% and the NTG, 21% of necrosis, a difference statistically significant (P < 0.001).Conclusion: TENS was effective in the reduction of necrosis in this flap model.en
dc.description.affiliationUNIFESP, Plast Surg Div, São Paulo, SP, Brazil
dc.description.affiliationUNIFESP, Dept Ophthalmol, São Paulo, SP, Brazil
dc.description.affiliationUnifespUNIFESP, Plast Surg Div, São Paulo, SP, Brazil
dc.description.affiliationUnifespUNIFESP, Dept Ophthalmol, São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent670-672
dc.identifierhttp://dx.doi.org/10.1097/01.sap.0000235503.74038.a9
dc.identifier.citationAnnals of Plastic Surgery. Philadelphia: Lippincott Williams & Wilkins, v. 57, n. 6, p. 670-672, 2006.
dc.identifier.doi10.1097/01.sap.0000235503.74038.a9
dc.identifier.issn0148-7043
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29307
dc.identifier.wosWOS:000242318800017
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofAnnals of Plastic Surgery
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectrandom flapsen
dc.subjectnicotineen
dc.subjectTENSen
dc.subjectratsen
dc.titleTranscutaneous electrical nerve stimulation in viability of a random skin flap in nicotine-treated ratsen
dc.typeinfo:eu-repo/semantics/article
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