Neo-Timm staining in the thalamus of chronically epileptic rats

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dc.contributor.authorHamani, Clement [UNIFESP]
dc.contributor.authorPaulo, I. de [UNIFESP]
dc.contributor.authorMello, Luiz Eugenio Araujo de Moraes [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:31:47Z
dc.date.available2015-06-14T13:31:47Z
dc.date.issued2005-11-01
dc.description.abstractThe thalamus is an important modulator of seizures and is severely affected in cholinergic models of epilepsy. In the present study, chronically epileptic rats had their brains processed for neo-Timm and acetylcholinesterase two months after the induction of status epilepticus with pilocarpine. Both controls and pilocarpine-treated animals presented neo-Timm staining in the anterodorsal nucleus, laterodorsal nucleus, reticular nucleus, most intralaminar nuclei, nucleus reuniens, and rhomboid nucleus of the thalamus, as well as in the zona incerta. The intensity of neo-Timm staining was similar in control and pilocarpine-treated rats, except for the nucleus reuniens and the rhomboid nucleus, which had a lower intensity of staining in the epileptic group. In animal models of temporal lobe epilepsy, zinc seems to modulate glutamate release and to decrease seizure activity. In this context, a reduction of neo-Timm-stained terminals in the midline thalamus could ultimately result in an increased excitatory activity, not only within its related nuclei, but also in anatomical structures that receive their efferent connections. This might contribute to the pathological substrate observed in chronic pilocarpine-treated epileptic animals.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Fisiologia
dc.description.affiliationUnifespUNIFESP, EPM, Depto. de Fisiologia
dc.description.sourceSciELO
dc.format.extent1677-1682
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2005001100016
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 38, n. 11, p. 1677-1682, 2005.
dc.identifier.doi10.1590/S0100-879X2005001100016
dc.identifier.fileS0100-879X2005001100016.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2005001100016
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/2740
dc.identifier.wosWOS:000232915100016
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEpilepsyen
dc.subjectPilocarpineen
dc.subjectZincen
dc.subjectSproutingen
dc.subjectNucleus reuniensen
dc.subjectMidline thalamusen
dc.titleNeo-Timm staining in the thalamus of chronically epileptic ratsen
dc.typeinfo:eu-repo/semantics/article
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