Chlorella vulgaris restores bone marrow cellularity and cytokine production in lead-exposed mice

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dc.contributor.authorQueiroz, Mary L. S.
dc.contributor.authorRocha, Michelle C. da
dc.contributor.authorTorello, Cristiane O.
dc.contributor.authorQueiroz, Julia de Souza
dc.contributor.authorBincoletto, Claudia [UNIFESP]
dc.contributor.authorMorgano, Marcelo A.
dc.contributor.authorRomano, Miriam R.
dc.contributor.authorParedes-Gamero, Edgar Julian [UNIFESP]
dc.contributor.authorBarbosa, Christiano Marcello Vaz [UNIFESP]
dc.contributor.authorCalgarotto, Andrana K.
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionITAL
dc.date.accessioned2016-01-24T14:17:20Z
dc.date.available2016-01-24T14:17:20Z
dc.date.issued2011-11-01
dc.description.abstractChlorella vulgaris (CV) was examined for its modulating effects on the reduction induced by lead (Pb) on the numbers of marrow hematopoietic stem cells (HSCs) (c-Kit(+)Lin(-)), granulocyte-macrophage progenitors (Gr1(+)Mac1(+)) and total bone marrow cellularity. in mice gavage-treated daily with 50 mg/kg dose of CV for 10 days, concomitant to a continuous offering of 1300 ppm lead acetate in drinking water, the treatment with the algae recovered the significantly reduced numbers of these cell populations to control values. As CV may have a myelostimulating effect through the induction of cytokines, we evaluated its modulating effects on the production of IL-1 alpha, TNF-alpha, IFN-gamma, IL-10 and IL-6. Our results demonstrated that lead significantly impairs the production of IFN-gamma, IL-1 alpha and TNF-alpha and increases the production of IL-10 and IL-6 and that these effects are successfully modulated by the CV treatment. the activity of NK cells, reduced in Pb-exposed animals, was raised to levels higher than those of controls in the exposed group treated with CV. Treatment with the algae also stimulated the production of IFN-gamma, IL-1 alpha, TNF-alpha and NK cells activity in normal mice. in addition, zinc bone concentrations, reduced in lead-exposed mice, were partially, but significantly, reversed by the treatment with CV. (C) 2011 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Estadual Campinas, Dept Farmacol, Fac Ciencias Med, Hemoctr, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Farmacol, Escola Paulista Med, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biofis, Escola Paulista Med, São Paulo, Brazil
dc.description.affiliationITAL, Ctr Quim Alimentos & Nutr Aplicada, Campinas, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Farmacol, Escola Paulista Med, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biofis, Escola Paulista Med, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent2934-2941
dc.identifierhttp://dx.doi.org/10.1016/j.fct.2011.06.056
dc.identifier.citationFood and Chemical Toxicology. Oxford: Pergamon-Elsevier B.V., v. 49, n. 11, p. 2934-2941, 2011.
dc.identifier.doi10.1016/j.fct.2011.06.056
dc.identifier.fileWOS000296681600027.pdf
dc.identifier.issn0278-6915
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34158
dc.identifier.wosWOS:000296681600027
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofFood and Chemical Toxicology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectChlorella vulgarisen
dc.subjectLead acetateen
dc.subjectHematopoiesisen
dc.subjectNatural killer cellsen
dc.subjectCytokinesen
dc.subjectZinc concentrationsen
dc.titleChlorella vulgaris restores bone marrow cellularity and cytokine production in lead-exposed miceen
dc.typeinfo:eu-repo/semantics/article
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