Impact of nutritional recovery with linear growth on the concentrations of adipokines in undernourished children living in Brazilian slums

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dc.contributor.authorMartins, Vinicius J. B. [UNIFESP]
dc.contributor.authorNeves, Andrea P. O. [UNIFESP]
dc.contributor.authorFranco, Maria do C. P. [UNIFESP]
dc.contributor.authorClemente, Ana P. G.
dc.contributor.authorSawaya, Ana L. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Fed Alagoas
dc.date.accessioned2016-01-24T14:37:53Z
dc.date.available2016-01-24T14:37:53Z
dc.date.issued2014-09-28
dc.description.abstractUndernutrition in early life has been reported to be closely associated with the development of non-communicable diseases in adulthood. Adequate treatment is important for reversing these effects. in the present study, we investigated the effects of undernutrition and anthropometric recovery on the weights and heights of children in relation to the concentrations of leptin, adiponectin and plasminogen activator inhibitor-1 (PAI-1). A total of 119 children (aged 616 years) from the slums of São Paulo were selected according to their nutritional status and divided into three groups as follows: control (healthy without intervention, n 38) with a height-for-age Z score (HAZ) and a BMI-for-age Z score (BAZ) > - 1.6; undernourished (HAZ and/or BAZ < - 1.6, n 54); recovered from undernutrition (after treatment in a rehabilitation centre; HAZ and BAZ > - 1.6, n 27). Blood samples were collected to determine insulin, glucose, leptin, adiponectin and PAI-1 concentrations. Leptin concentrations in the undernourished group were lower than those in the control and recovered groups (mean 0.92 (95 % CI 0.67, 1.25), 2.03 (95 % CI 1.46, 2.82) and 1.66 (95 % CI 1.15, 2.44) ng/ml, P=0.003), which had similar leptin concentrations. There were no differences in adiponectin and PAI-1 concentrations among the groups. A positive correlation between waist circumference and leptin concentrations was observed in all the girls and boys of the control group (control: r 0.729, P<0.01; undernourished: r 0.490, P<0.05; and recovered: r 0.829, P<0.01; r 0.673, P<0.05). Stronger correlations between leptin and insulin concentrations were observed in the recovered group. the results of the present study indicate that normal leptin concentrations are found when normal height and weight are achieved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Physiol, BR-04023060 São Paulo, Brazil
dc.description.affiliationUniv Fed Alagoas, Fac Nutr, BR-57072900 Maceio, AL, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Physiol, BR-04023060 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 2010/51237-2
dc.description.sponsorshipIDCNPq: 302740/2010-4
dc.format.extent937-944
dc.identifierhttp://dx.doi.org/10.1017/S0007114514001743
dc.identifier.citationBritish Journal of Nutrition. Cambridge: Cambridge Univ Press, v. 112, n. 6, p. 937-944, 2014.
dc.identifier.doi10.1017/S0007114514001743
dc.identifier.issn0007-1145
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38232
dc.identifier.wosWOS:000341970800009
dc.language.isoeng
dc.publisherCambridge Univ Press
dc.relation.ispartofBritish Journal of Nutrition
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://journals.cambridge.org/action/displaySpecialPage?pageId=4676
dc.subjectAdipokinesen
dc.subjectUndernutritionen
dc.subjectNutritional recoveryen
dc.titleImpact of nutritional recovery with linear growth on the concentrations of adipokines in undernourished children living in Brazilian slumsen
dc.typeinfo:eu-repo/semantics/article
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