Histopathological Study of Delayed Regraft After Corneal Graft Failure

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dc.contributor.authorSantos, Leonardo N. [UNIFESP]
dc.contributor.authorMoura, Leticia Rielo de [UNIFESP]
dc.contributor.authorFernandes, Bruno F. [UNIFESP]
dc.contributor.authorCheema, Devinder P.
dc.contributor.authorBurnier, Miguel N. [UNIFESP]
dc.contributor.institutionMcGill Univ
dc.contributor.institutionHenry C Witelson Ocular Pathol Lab
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:06:09Z
dc.date.available2016-01-24T14:06:09Z
dc.date.issued2011-02-01
dc.description.abstractPurpose: To evaluate the histopathological features of corneal graft failures over time.Methods: A single-center retrospective analysis was performed on corneal specimens diagnosed as corneal graft failure retrieved from the Henry C. Witelson Ophthalmic Pathology Laboratory and Registry (Montreal, Canada) over a 9-year period. the corneal buttons were divided into 3 different groups according to the time between the diagnosis of corneal graft failure and regraft. Corneal specimens obtained during keratoplasty were subjected to hematoxylin and eosin and periodic acid-Schiff. Five different histopathological findings were evaluated in each specimen.Results: Overall, the most common histopathological finding was endothelial decompensation (97.2%). Subepithelial pannus (38.9%), vessels in the corneal stroma (11.1%), and anterior synechiae (2.8%) were the other present findings. the inflammatory reaction was considered discrete in 83.3% of the cases. the only significant histopathological finding correlated with time was the presence of vessels in the corneal stroma (P = 0.0092).Conclusions: Corneal neovascularization, represented by the presence of vessels in the corneal stroma, was the only histopathological finding correlated with time. Because it is a known factor of poor prognosis, our findings strongly support that early regraft has higher chances of success.en
dc.description.affiliationMcGill Univ, Ctr Hlth, Dept Ophthalmol & Pathol, Montreal, PQ, Canada
dc.description.affiliationHenry C Witelson Ocular Pathol Lab, Montreal, PQ, Canada
dc.description.affiliationUniversidade Federal de São Paulo, UNIFESP EPM, Dept Ophthalmol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, UNIFESP EPM, Dept Ophthalmol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent167-170
dc.identifierhttp://dx.doi.org/10.1097/ICO.0b013e3181e843e5
dc.identifier.citationCornea. Philadelphia: Lippincott Williams & Wilkins, v. 30, n. 2, p. 167-170, 2011.
dc.identifier.doi10.1097/ICO.0b013e3181e843e5
dc.identifier.issn0277-3740
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33435
dc.identifier.wosWOS:000285914700011
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofCornea
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjecthistopathologyen
dc.subjectcornealen
dc.subjectgraften
dc.subjectfailureen
dc.titleHistopathological Study of Delayed Regraft After Corneal Graft Failureen
dc.typeinfo:eu-repo/semantics/article
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