Gene polymorphism of interleukin 1 and 8 in chronic gastritis patients infected with Helicobacter pylori

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dc.contributor.authorCaleman Neto, Agostinho
dc.contributor.authorRasmussen, Lucas T.
dc.contributor.authorLabio, Roger W. de
dc.contributor.authorQueiroz, Valdeir F. de
dc.contributor.authorSmith, Marilia de A. C. [UNIFESP]
dc.contributor.authorViani, Gustavo A.
dc.contributor.authorPayao, Spencer L. M.
dc.contributor.institutionMarilia Med Sch FAMEMA
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionFAMEMA
dc.date.accessioned2016-01-24T14:37:08Z
dc.date.available2016-01-24T14:37:08Z
dc.date.issued2014-04-23
dc.description.abstractBackground: Epidemiological investigations have indicated that Helicobacter pylori induces inflammation in the gastric mucosa regulated by several interleukins. the genes IL1B and IL8 are suggested as key factors in determining the risk of gastritis. the aim of this paper was to evaluate the association of gene polymorphism of interleukin-1 and interleukin-8 with chronic gastrits in H. pylori infected patients. A total of 60 patients underwent endoscopic procedure. Biopsy samples were collected for urease test, histopathological and molecular exams. the DNA of theses samples was extracted for detection of H. pylori and analysis of the genes mentioned above. Patients with gastritis had a higher frequency of H. pylori-positive samples.Results: H. pylori was detected in 30/60 patients (50%) by PCR. As for polymorphism of interleukin 8 (-251) gene we observed a statistical difference when analyzed TA (p = 0.039) and TT (p = 0.047) genotypes. in the IL1B31 there was a statistical difference in TT (p = 0.01) genotype and in the IL1B-511 there wasn't any statistical difference.Conclusion: Our results suggest a strong correlation between the presence of chronic gastritis and infection by H. pylori and that IL1B-31TT and IL8-251TT genotypes appear to act as protective factors against H. pylori infection while IL8-251TA genotype may comprise a risk factor for infection with this bacterium.en
dc.description.affiliationMarilia Med Sch FAMEMA, FAMEMA Blood Ctr, Dept Genet, Marilia, SP, Brazil
dc.description.affiliationSacred Heart Univ USC, Bauru, SP, Brazil
dc.description.affiliationMarilia Med Sch FAMEMA, Dept Digest Syst Surg, Marilia, SP, Brazil
dc.description.affiliationFed Univ São Paulo UNIFESP, Dept Morphol, São Paulo, Brazil
dc.description.affiliationMarilia Med Sch FAMEMA, Dept Radiotherapy & Oncol, Marilia, SP, Brazil
dc.description.affiliationFAMEMA, Hemoctr, Genet Lab, BR-17519050 São Paulo, Brazil
dc.description.affiliationUnifespFed Univ São Paulo UNIFESP, Dept Morphol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipMarilia Medical School
dc.description.sponsorshipIDFAPESP: 0915857-9
dc.format.extent5
dc.identifierhttp://dx.doi.org/10.1186/1678-9199-20-17
dc.identifier.citationJournal of Venomous Animals and Toxins Including Tropical Diseases. London: Biomed Central Ltd, v. 20, 5 p., 2014.
dc.identifier.doi10.1186/1678-9199-20-17
dc.identifier.fileWOS000335412400001.pdf
dc.identifier.issn1678-9199
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37676
dc.identifier.wosWOS:000335412400001
dc.language.isoeng
dc.publisherBiomed Central Ltd
dc.relation.ispartofJournal of Venomous Animals and Toxins Including Tropical Diseases
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHelicobacter pylorien
dc.subjectPolymorphismen
dc.subjectInterleukinen
dc.titleGene polymorphism of interleukin 1 and 8 in chronic gastritis patients infected with Helicobacter pylorien
dc.typeinfo:eu-repo/semantics/article
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