The effect of sildenafil on sleep respiratory parameters and heart rate variability in obstructive sleep apnea

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dc.contributor.authorNeves, Christiane [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorMonteiro, Marina Ariza [UNIFESP]
dc.contributor.authorChediek, Felipe [UNIFESP]
dc.contributor.authorJose, Fabio Freire [UNIFESP]
dc.contributor.authorRoizenblatt, Suely [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:59:46Z
dc.date.available2016-01-24T13:59:46Z
dc.date.issued2010-06-01
dc.description.abstractObjective: To evaluate the magnitude of effects of sildenafil on respiratory parameters and heart rate variability (HRV) in slow wave sleep (SWS) and REM sleep of patients with severe obstructive sleep apnea (OSA).Methods: Thirteen male patients with untreated severe OSA (aged 43 +/- 10 years, body mass index of 26.7 +/- 1.9 kg/m(2)) were studied on two nights, one with sildenafil 50 mg and one with a placebo, in a double-blind, randomized fashion. All-night polysomnography and HRV were simultaneously recorded. Short-term HRV measures were performed in apnea-free intervals. Respiratory parameters were separately assessed in non-REM and REM sleep and compared to total sleep time (TST). Short-term HRV analysis was conducted in samples with regular respiration obtained in SWS and REM sleep.Results: Comparing to placebo, during sildenafil night there was an increase in apnea-hypopnea index (AHI) in TST and also in non-REM and REM sleep. Increase in central AHI occurred in non-REM sleep; increase in obstructive AHI and decrease in oxyhemoglobin saturation occurred in both non-REM and REM sleep. Additionally, an increase in arousal index and in low/high frequency component of HRV ratio (LF/HF) was significant only in REM sleep. Correlation between sleep architecture and respiratory parameters were more frequent in non-REM sleep for placebo and in REM sleep for sildenafil.Conclusion: in severe OSA, the use of sildenafil 50 mg at bedtime plays a detrimental role on respiratory parameters in both non-REM and REM sleep, fragmentation in REM sleep, and a prolonged increase in LH/HF component of HRV after resumption of ventilation. (C) 2010 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, BR-01228200 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Internal Med, BR-01228200 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, BR-01228200 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Internal Med, BR-01228200 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipAssociacao Fundo Incentivo a Psicofarmacologia
dc.format.extent545-551
dc.identifierhttp://dx.doi.org/10.1016/j.sleep.2010.02.010
dc.identifier.citationSleep Medicine. Amsterdam: Elsevier B.V., v. 11, n. 6, p. 545-551, 2010.
dc.identifier.doi10.1016/j.sleep.2010.02.010
dc.identifier.issn1389-9457
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32601
dc.identifier.wosWOS:000279424800008
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofSleep Medicine
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectApneaen
dc.subjectSleepen
dc.subjectSildenafilen
dc.subjectHeart rate variabilityen
dc.subjectHypoxemiaen
dc.subjectNitric oxideen
dc.titleThe effect of sildenafil on sleep respiratory parameters and heart rate variability in obstructive sleep apneaen
dc.typeinfo:eu-repo/semantics/article
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