An overview on frequency of renal biopsy diagnosis in Brazil: clinical and pathological patterns based on 9617 native kidney biopsies

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dc.contributor.authorPolito, Maria Goretti [UNIFESP]
dc.contributor.authorRibeiro de Moura, Luiz Antonio [UNIFESP]
dc.contributor.authorKirsztajn, Gianna Mastroianni [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:59:12Z
dc.date.available2016-01-24T13:59:12Z
dc.date.issued2010-02-01
dc.description.abstractBackground. Studies about the prevalence of renal and particularly glomerular diseases in Brazil are still scarce.Methods. We evaluated retrospectively the reports of 9,617 renal biopsies, analyzed by the same pathologist, from January 1993 to December 2007.Results. the 9,617 renal biopsies performed in subjects of all ages in native kidneys. 4,619 were primary glomerulopathies (GN), the most frequent was focal segmental glomerulosclerosis (FSGS, 24.6%), followed by membranous nephropathy (MN, 20.7%), IgA nephropathy (IgAN, 20.1%), minimal change disease (MCD, 15.5%), mesangioproliferative non IgAN (nonIgAN, 5.2%), diffuse proliferative GN (DPGN, 4.7%) and membranoproliferative GN (MPGN, 4.2%). Lupus nephritis was responsible for most cases which etiology was determined, i.e., 950 out of 2,046 cases (45.5%), followed by post infectious GN (18.9%), diabetic nephropathy (8.5%), benign and malignant nephroangiosclerosis (7.3%), haemolytic-uraemic syndrome and thrombotic thrombocytopenic purpura (HUS/TTP), amyloidosis (4.8%) and vasculitis (4.7%). There was a predominance of secondary GN in the North, mostly due to lupus nephritis (LN); FSGS was very common in Northeast (27.7%), Central (26.9%) and Southeast regions (24.1%); IgAN was most frequent in South (22.8%) and MN in North (29.6%); the total prevalence of MPGN was low, and its regional distribution has not changed along the years.Conclusion. FSGS was the most frequent primary glomerular disease, followed closely by MN and IgAN. the predominance of FSGS is in accordance with recent studies all over the world that revealed its frequency is increasing. Lupus nephritis predominated among secondary GN in most regions, a finding observed in other studies.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Med, Div Nephrol, Glomerulopathy Sect, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Med, Div Nephrol, Glomerulopathy Sect, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent490-496
dc.identifierhttp://dx.doi.org/10.1093/ndt/gfp355
dc.identifier.citationNephrology Dialysis Transplantation. Oxford: Oxford Univ Press, v. 25, n. 2, p. 490-496, 2010.
dc.identifier.doi10.1093/ndt/gfp355
dc.identifier.issn0931-0509
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32187
dc.identifier.wosWOS:000273891600028
dc.language.isoeng
dc.publisherOxford Univ Press
dc.relation.ispartofNephrology Dialysis Transplantation
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.oxfordjournals.org/access_purchase/self-archiving_policyb.html
dc.subjectepidemiologyen
dc.subjectglomerulopathyen
dc.subjectprevalenceen
dc.subjectrenal biopsyen
dc.subjectrenal diseasesen
dc.titleAn overview on frequency of renal biopsy diagnosis in Brazil: clinical and pathological patterns based on 9617 native kidney biopsiesen
dc.typeinfo:eu-repo/semantics/article
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