Gender and hemispheric differences in temporal lobe epilepsy: A VBM study

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dc.contributor.authorSantana, Maria Teresa Castilho Garcia de [UNIFESP]
dc.contributor.authorJackowski, Andrea Parolin [UNIFESP]
dc.contributor.authorBritto, Fernanda dos Santos [UNIFESP]
dc.contributor.authorSandim, Gabriel Barbosa [UNIFESP]
dc.contributor.authorCaboclo, Luís Otávio Sales Ferreira [UNIFESP]
dc.contributor.authorCenteno, Ricardo Silva [UNIFESP]
dc.contributor.authorCarrete Junior, Henrique [UNIFESP]
dc.contributor.authorYacubian, Elza Márcia Targas [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:35:28Z
dc.date.available2016-01-24T14:35:28Z
dc.date.issued2014-04-01
dc.description.abstractPurpose: Gender differences are recognized in the functional and anatomical organization of the human brain. Differences between genders are probably expressed early in life, when differential rates of cerebral maturation occur. Sexual dimorphism has been described in temporal lobe epilepsy with mesial temporal sclerosis (TLE-MTS). Several voxel-based morphometry (VBM) studies have shown that TLE-MTS extends beyond mesial temporal structures, and that there are differences in the extent of anatomical damage between hemispheres, although none have approached gender differences. Our aim was to investigate gender differences and anatomical abnormalities in TLE-MTS.Methods: VBM5 was employed to analyze gender and hemispheric differences in 120 patients with TLE-MTS and 50 controls.Results: VBM abnormalities were more widespread in left-TLE; while in women changes were mostly seen in temporal areas, frontal regions were more affected in men.Conclusions: Our study confirmed that gender and laterality are important factors determining the nature and severity of brain damage in TLE-MTS. Differential rates of maturation between gender and hemispheres may explain the distinct areas of anatomical damage in men and women. (C) 2013 British Epilepsy Association. Published by Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Unidade Pesquisa & Tratamento Epilepsias UNIPETE, Dept Neurol & Neurosurg, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychiat, Lab Interdisciplinar Neurociencias Clin LiNC, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Diagnost Imagem, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Unidade Pesquisa & Tratamento Epilepsias UNIPETE, Dept Neurol & Neurosurg, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychiat, Lab Interdisciplinar Neurociencias Clin LiNC, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Diagnost Imagem, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent274-279
dc.identifierhttp://dx.doi.org/10.1016/j.seizure.2013.12.006
dc.identifier.citationSeizure-european Journal of Epilepsy. London: W B Saunders Co Ltd, v. 23, n. 4, p. 274-279, 2014.
dc.identifier.doi10.1016/j.seizure.2013.12.006
dc.identifier.fileWOS000334980700005.pdf
dc.identifier.issn1059-1311
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37568
dc.identifier.wosWOS:000334980700005
dc.language.isoeng
dc.publisherW B Saunders Co Ltd
dc.relation.ispartofSeizure-european Journal of Epilepsy
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGenderen
dc.subjectMesial temporal sclerosisen
dc.subjectTemporal lobe epilepsyen
dc.subjectVoxel-based morphometryen
dc.titleGender and hemispheric differences in temporal lobe epilepsy: A VBM studyen
dc.typeinfo:eu-repo/semantics/article
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