The relationship between nutritional status, vitamin A and zinc levels and oxidative stress in patients with ataxia-telangiectasia

Página do item simplificado
dc.contributor.authorSilva, R. da [UNIFESP]
dc.contributor.authorSantos-Valente, E. C. dos [UNIFESP]
dc.contributor.authorScomparini, F. Burim [UNIFESP]
dc.contributor.authorSarni, Roseli Oselka Saccardo [UNIFESP]
dc.contributor.authorCosta-Carvalho, B. T. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Fed Alfenas
dc.contributor.institutionABC Univ
dc.date.accessioned2016-01-24T14:37:31Z
dc.date.available2016-01-24T14:37:31Z
dc.date.issued2014-07-01
dc.description.abstractBackground: Ataxia-telangiectasia (A-T) is a rare and degenerative disease that leads to varying degrees of immunodeficiency, oxidative stress, and malnutrition. Vitamin A and zinc are essential for immune function and antioxidant defence.Objective: To compare levels of retinol, beta carotene, and zinc in patients with ataxia-telangiectasia and healthy controls.Methods: We performed a cross-sectional study with 14 AT patients and 14 healthy controls matched for age and gender. All participants underwent a nutritional and laboratory evaluation comprising concentrations of retinol, beta carotene, serum and erythrocyte zinc, malondialdehyde (MDA), T lymphocyte numbers (CD4(+) and CD8(+)) and immunoglobulin (IgA).Results: the AT patients showed high rates of malnutrition with reduced lean body mass when compared to the control group. However, the concentrations of MDA, retinol, beta carotene, and serum and erythrocyte zinc in AT patients were similar to those of the control group. the retinol levels presented a negative correlation with MDA and positive correlation with IgA serum level.Conclusions: the AT patients assessed showed no change in nutritional status for vitamin A and zinc; however, they presented severe impairment in overall nutritional status observed and correlation between retinol with MDA and IgA. (C) 2012 SEICAP. Published by Elsevier Espana, S.L. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliationUniv Fed Alfenas, Alfenas, MG, Brazil
dc.description.affiliationABC Univ, Santo Andre, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 08705-5/2008
dc.format.extent329-335
dc.identifierhttp://dx.doi.org/10.1016/j.aller.2013.02.013
dc.identifier.citationAllergologia Et Immunopathologia. Barcelona: Elsevier Doyma Sl, v. 42, n. 4, p. 329-335, 2014.
dc.identifier.doi10.1016/j.aller.2013.02.013
dc.identifier.issn0301-0546
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37931
dc.identifier.wosWOS:000339227000011
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofAllergologia Et Immunopathologia
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectAtaxia-telangiectasiaen
dc.subjectOxidative stressen
dc.subjectRetinolen
dc.subjectZincen
dc.subjectNutritional statusen
dc.subjectImmune systemen
dc.titleThe relationship between nutritional status, vitamin A and zinc levels and oxidative stress in patients with ataxia-telangiectasiaen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
Em verificação - Geral