Voxel-based morphometry evaluation of patients with photosensitive juvenile myoclonic epilepsy

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dc.contributor.authorLin, Katia [UNIFESP]
dc.contributor.authorJackowski, Andrea Parolin [UNIFESP]
dc.contributor.authorCarrete Junior, Henrique [UNIFESP]
dc.contributor.authorAraujo Filho, Gerardo Maria de [UNIFESP]
dc.contributor.authorSilva, Henrique Hattori [UNIFESP]
dc.contributor.authorBittar Guaranha, Mirian Salvadori [UNIFESP]
dc.contributor.authorFigueiredo Ferreira Guilhoto, Laura Maria [UNIFESP]
dc.contributor.authorBressan, Rodrigo Affonseca [UNIFESP]
dc.contributor.authorTargas Yacubian, Elza Marcia [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:58:48Z
dc.date.available2016-01-24T13:58:48Z
dc.date.issued2009-10-01
dc.description.abstractWe aim to investigate structural brain abnormalities in juvenile myoclonic epilepsy (JME) patients with photosensitivity (PS). Sixty JME patients, 19 (32%) of whom were photosensitive, were submitted to 1.5 T magnetic resonance voxel-based morphometry (VBM). the control group (CTL) consisted of 30 sex-matched healthy volunteers. JME patients with (JME-PS) and without (JME-NPS) PS did not differ in their duration of disease, treatment or seizure control. VBM revealed significantly reduced bilateral gray matter volume (GMV) in thalami, insula cortices and cerebellar hemispheres; while significantly increased GMV was observed in the right superior frontal, orbitofrontal and medial. frontal gyri of the JME group compared to CTL. JME-PS had reduced bilateral GMV of visual cortices when compared with CTL; white it was not seen among JME-NPS patients. Reduced left hippocampus and left inferior frontal gyrus volume was observed among JME-PS compared with JME-NPS. This study demonstrates structural abnormalities beyond the limits of the frontal lobes and provides evidence for the role of the occipital cortex in human PS, reinforcing the existence of functional-anatomic ictogenic networks in JME and the concept of 'system epitepsies'. (C) 2009 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, EPM, UNIPETE, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, EPM, LiNC, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, EPM, Dept Diagnost Imagem, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, EPM, UNIPETE, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, EPM, LiNC, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, EPM, Dept Diagnost Imagem, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent138-145
dc.identifierhttp://dx.doi.org/10.1016/j.eplepsyres.2009.05.016
dc.identifier.citationEpilepsy Research. Amsterdam: Elsevier B.V., v. 86, n. 2-3, p. 138-145, 2009.
dc.identifier.doi10.1016/j.eplepsyres.2009.05.016
dc.identifier.issn0920-1211
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31859
dc.identifier.wosWOS:000271150600005
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofEpilepsy Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectMagnetic resonance imagingen
dc.subjectVoxel-based morphometryen
dc.subjectIdiopathic generalized epilepsyen
dc.subjectJuvenile myoclonic epilepsyen
dc.subjectPhotosensitivityen
dc.titleVoxel-based morphometry evaluation of patients with photosensitive juvenile myoclonic epilepsyen
dc.typeinfo:eu-repo/semantics/article
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