Correlation between serum E-selectin levels and panoramic nailfold capillaroscopy in systemic sclerosis

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dc.contributor.authorValim, Valeria [UNIFESP]
dc.contributor.authorAssis, L.s.s. [UNIFESP]
dc.contributor.authorSimões, Marcia F. J.[UNIFESP]
dc.contributor.authorTrevisani, Virgínia Fernandes Moça [UNIFESP]
dc.contributor.authorPucinelli, Mário Luis Cardoso [UNIFESP]
dc.contributor.authorAndrade, Luiz Eduardo Coelho [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:31:15Z
dc.date.available2015-06-14T13:31:15Z
dc.date.issued2004-09-01
dc.description.abstractE-selectin is expressed by the activated endothelium and its plasma levels are increased in patients with systemic sclerosis. Eighteen patients fulfilling the American Rheumatism Association criteria for systemic sclerosis, 15 females and 3 males, 42-70 years old, 9 with diffuse and 9 with limited forms, were sequentially recruited for this study. Serum E-selectin levels were determined by commercially available ELISA and their association with nailfold capillaroscopic abnormalities was investigated. Nailfold capillaries were analyzed by 16X magnification wide-field capillaroscopy. Two parameters on capillaroscopy were used to correlate to serum E-selectin: deletion and ectasia. Data were analyzed statistically by the Student t-test and Spearman correlation. Two-tailed P values below 0.05 were considered significant. E-selectin range was 38 to 200 ng/ml (80 ± 39.94). There was a correlation between serum E-selectin levels and the deletion capillaroscopic score (r = 0.50, P < 0.035). This correlation was even stronger within the first 48 months of diagnosis (r = 0.63, P < 0.048). On the other hand, no association was observed between selectin and ectasia. Patients with diffuse disease presented higher serum E-selectin levels than patients with limited disease, although the difference was not statistically significant (96.44 ± 48.04 vs 63.56 ± 21.77 ng/dl; P = 0.08). The present study is the first showing a correlation between soluble serum E-selectin levels and alterations in capillaroscopy. The stronger correlation of deletion score in capillaroscopy in early disease suggests that serum E-selectin levels might be a useful biochemical marker of disease activity in systemic sclerosis.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Divisão de Reumatologia
dc.description.affiliationUnifespUNIFESP, EPM, Divisão de Reumatologia
dc.description.sourceSciELO
dc.format.extent1423-1427
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2004000900018
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 37, n. 9, p. 1423-1427, 2004.
dc.identifier.doi10.1590/S0100-879X2004000900018
dc.identifier.fileS0100-879X2004000900018.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2004000900018
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/2215
dc.identifier.wosWOS:000223707100018
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSystemic sclerosisen
dc.subjectNailfold capillaroscopyen
dc.subjectE-selectinen
dc.subjectAdhesion moleculesen
dc.titleCorrelation between serum E-selectin levels and panoramic nailfold capillaroscopy in systemic sclerosisen
dc.typeinfo:eu-repo/semantics/article
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