Plasmablastic multiple myeloma is associated with increased vascular endothelial growth factor immunoexpression

Página do item simplificado
dc.contributor.authorRibas, C. [UNIFESP]
dc.contributor.authorColleoni, Gisele Wally Braga [UNIFESP]
dc.contributor.authorAlmeida, M.s.s. [UNIFESP]
dc.contributor.authorAguiar, K.c.c. [UNIFESP]
dc.contributor.authorSilva, M.r.r. [UNIFESP]
dc.contributor.authorBordin, Jose Orlando [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:31:47Z
dc.date.available2015-06-14T13:31:47Z
dc.date.issued2005-11-01
dc.description.abstractThe biologic basis of the negative prognosis of plasmablastic myeloma is not fully understood. To determine whether histologically aggressive multiple myeloma (MM) is associated with a more angiogenic marrow environment, bone marrow samples from 50 recently diagnosed MM patients were evaluated. Twelve percent (6/50) of patients presented plasmablastic MM, and this feature correlated with moderate/strong intensity of vascular endothelial growth factor staining of plasma cells (P = 0.036). Although plasmablastic MM was not associated with increasing of microvessel density, this new evidence of increased expression of vascular endothelial growth factor on plasmablasts suggests that the adverse prognosis conferred by plasmablastic disease may be due, at least in part, to secretion of this angiogenic cytokine, also suggesting that the subset of MM patients with plasmablastic features may derive particular benefit from antiangiogenic therapies.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Disciplina de Hematologia e Hemoterapia
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Patologia
dc.description.affiliationUnifespUNIFESP, EPM, Disciplina de Hematologia e Hemoterapia
dc.description.affiliationUnifespUNIFESP, EPM, Depto. de Patologia
dc.description.sourceSciELO
dc.format.extent1609-1613
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2005001100007
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 38, n. 11, p. 1609-1613, 2005.
dc.identifier.doi10.1590/S0100-879X2005001100007
dc.identifier.fileS0100-879X2005001100007.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2005001100007
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/2745
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMultiple myelomaen
dc.subjectAngiogenesisen
dc.subjectVascular endothelial growth factoren
dc.titlePlasmablastic multiple myeloma is associated with increased vascular endothelial growth factor immunoexpressionen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
S0100-879X2005001100007.pdf
Tamanho:
661.94 KB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Coleções
EPM - Artigos