Glomerular detection of schistosomal antigen by immunoelectron microscopy in human mansonian schistosomiasis

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dc.contributor.authorBrito, Thales de [UNIFESP]
dc.contributor.authorNussenzveig, Israel
dc.contributor.authorCarneiro, Celia Regina Whitaker [UNIFESP]
dc.contributor.authorNakhle, Maria Cristina
dc.contributor.authorCarvalho, S.
dc.contributor.authorSilva, Ana Maria G
dc.contributor.authorSandoval, Marina
dc.contributor.authorSaldanha, L. B.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:30:54Z
dc.date.available2016-01-24T12:30:54Z
dc.date.issued1999-10-01
dc.description.abstractSchistosomal antigens (S. mansoni) were detected in glomeruli of nine patients with nephropathy and nephrotic syndrome by immunoelectron microscopy. the criteria for patients' selection were presence of intestinal schistosomiasis and absence of any surgical or other medical diseases, particularly lupus erythematosus, syphilis, and hepatitis B and C, which could explain the renal disease. When examined by light microscopy, kidney biopsies showed type I membranoproliferative glomerulonephritis in four patients, focal segmental glomerulosclerosis in two, and mesangioproliferative glomerulonephritis, membranous glomerulonephritis, and minimal change disease in one each of the remaining three patients. Immunofluorescence showed mainly immunoglobulin G (IgG), IgM, and different complement components (C3, C1q) deposits, particularly in the mesangial area, in eight patients. All patients had gold-labeled schistosomal antigen deposits in their glomeruli, chiefly in mesangial cells and matrix, along the glomerular membrane, and occasionally in the cytoplasm of epithelial cells. Although membranous glomerulonephritis has been rarely described in association with schistosomiasis and minimal change disease may be occasionally caused by an infectious disease like syphilis, the absence of definite experimental models and epidemiologic data suggests that coincidental pathologies without causal relationship with schistosomiasis cannot be ruled our to explain these findings.en
dc.description.affiliationUniv São Paulo, Sch Med, Hosp Clin, Inst Trop Med,Dept Pathol, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Sch Med, Hosp Clin, Inst Trop Med,Dept Nephrol, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Sch Med, Hosp Clin, Inst Trop Med,Dept Infect Dis, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent217-225
dc.identifierhttps://dx.doi.org/10.1177/106689699900700404
dc.identifier.citationInternational Journal of Surgical Pathology. Glen Head: Westminster Publ Inc, v. 7, n. 4, p. 217-225, 1999.
dc.identifier.doi10.1177/106689699900700404
dc.identifier.issn1066-8969
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/26159
dc.identifier.wosWOS:000083483000004
dc.language.isoeng
dc.publisherWestminster Publ Inc
dc.relation.ispartofInternational Journal of Surgical Pathology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectSchistosomiasis mansonien
dc.subjectAntigenen
dc.subjectImmunoelectron microscopyen
dc.subjectHuman schistosomal nephropathyen
dc.titleGlomerular detection of schistosomal antigen by immunoelectron microscopy in human mansonian schistosomiasisen
dc.typeinfo:eu-repo/semantics/article
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