Increased angiogenesis in primary myelofibrosis: latent transforming growth factor-β as a possible angiogenic factor

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dc.contributor.authorPonce, Cesar Cilento
dc.contributor.authorChauffaille, Maria de Lourdes Lopes Ferrari [UNIFESP]
dc.contributor.authorIhara, Silvia Saiuli Miki [UNIFESP]
dc.contributor.authorSilva, Maria Regina Regis
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:47:21Z
dc.date.available2015-06-14T13:47:21Z
dc.date.issued2014-10-01
dc.description.abstractObjective: The aim of this work was to demonstrate a possible relationship between anti-latency-associated peptide human latent transforming growth factor beta 1 (latent TGF-β1) expression in megakaryocytes and microvascular density in bone marrow biopsies from patients with essential thrombocythemia and primary myelofibrosis. Methods: Microvascular density was evaluated by immunohistochemical analysis and the expression of latent TGF-β1 in samples (100 megakaryocytes per bone marrow sample) from 18 essential thrombocythemia and 38 primary myelofibrosis (19 prefibrotic and 19 fibrotic) patients. Six bone marrow donor biopsies were used as controls. Fibrosis in the bone marrow biopsies was evaluated according to the European Consensus. Results: The average fibrosis grade differed between essential thrombocythemia and primary myelofibrosis groups when compared to the control group. Latent TGF-β1 expression differed significantly between the fibrotic primary myelofibrosis (PMF) group and the control group (p-value < 0.01). A high degree of neo-angiogenesis (demonstrated by analysis of CD34 expression) was detected in patients with myelofibrosis. There were correlations between latent TGF-β1 expression and microvascular density (r = 0.45; p-value < 0.0009) and between degree of microvascular density and fibrosis grade (r = 0.80; p-value < 0.0001). Remarkable differences for neo-angiogenesis were not observed between patients with essential thrombocythemia and controls. Conclusion: Angiogenesis participates in the pathogenesis of primary myelofibrosis, in both the prefibrotic and fibrotic stages, while latent TGF-β is differentially expressed only in the prefibrotic stage.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUnifespUNIFESP
dc.description.sourceSciELO
dc.format.extent322-328
dc.identifierhttp://dx.doi.org/10.1016/j.bjhh.2014.07.010
dc.identifier.citationRevista Brasileira de Hematologia e Hemoterapia. Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular, v. 36, n. 5, p. 322-328, 2014.
dc.identifier.doi10.1016/j.bjhh.2014.07.010
dc.identifier.fileS1516-84842014000500322.pdf
dc.identifier.issn1516-8484
dc.identifier.scieloS1516-84842014000500322
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/8637
dc.language.isoeng
dc.publisherAssociação Brasileira de Hematologia e Hemoterapia e Terapia Celular
dc.relation.ispartofRevista Brasileira de Hematologia e Hemoterapia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAngiogenesis inducing agentsen
dc.subjectPrimary myelofibrosisen
dc.subjectTransforming growth factor betaen
dc.subjectAntigens, CD34en
dc.subjectFibrosisen
dc.titleIncreased angiogenesis in primary myelofibrosis: latent transforming growth factor-β as a possible angiogenic factoren
dc.typeinfo:eu-repo/semantics/article
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