An overview about oxidation in clinical practice of skin aging

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dc.citation.issue3
dc.citation.volume92
dc.contributor.authorSilva, Silas Arandas Monteiro e [UNIFESP]
dc.contributor.authorMichniak-Kohn, Bozena
dc.contributor.authorLeonardi, Gislaine Ricci
dc.coverageRio De Janeiro Rj
dc.date.accessioned2020-07-13T11:53:17Z
dc.date.available2020-07-13T11:53:17Z
dc.date.issued2017
dc.description.abstractFree radicals are unstable chemical species, highly reactive, being formed by cellular entities of different tissues. Increased production of these species without proper effective action of endogenous and exogenous antioxidant systems, generates a condition of oxidative stress, potentially provider of skin disorders that extend from functional impairments (skin cancer, dermatitis, chronic and acute inflammatory processes) even aesthetic character, with the destruction of structural proteins and cellular changes with the appearance of stains, marks and lines of expressions and other signs inherent to the intrinsic and extrinsic skin aging process. The antioxidants are chemical substances commonly used in clinical practice for topical application and may contribute in the fight against the radical species responsible for many skin damage. This paper summarized the main evidence of the benefits brought by the topical application of antioxidants in the skin, considering the amplitude of the indicative performance of antioxidant activity by in vitro and ex-vivo tests as well as in vivo tests. It is recognized that a breadth of product performance tests should be explored to truly identify the effectiveness of antioxidant products for an anti-aging effect.en
dc.description.affiliationUniv Campinas UNICAMP, Fed Univ Sao Paulo UNIFESP, Postgrad Program Translat Med, Campinas, SP, Brazil
dc.description.affiliationUniv RUTGERS, New Brunswick, NJ USA
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Med, Sao Paulo, SP, Brazil
dc.description.affiliationRutgers State Univ, Dept Pharmaceut, Ernest Mario Sch Pharm, New Brunswick, NJ USA
dc.description.affiliationUniv Estadual Campinas UNICAMP, Fac Pharmaceut Sci, Campinas, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Dept Med, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipSao Paulo State Research Support Foundation
dc.description.sponsorshipNational Council for Scientific and Technological Development (CNPq)
dc.description.sponsorshipIDFAPESP: 2013-01118-5
dc.format.extent367-374
dc.identifierhttp://dx.doi.org/10.1590/abd1806-4841.20175481
dc.identifier.citationAnais Brasileiros De Dermatologia. Rio De Janeiro Rj, v. 92, n. 3, p. 367-374, 2017.
dc.identifier.doi10.1590/abd1806-4841.20175481
dc.identifier.fileS0365-05962017000300367.pdf
dc.identifier.issn0365-0596
dc.identifier.scieloS0365-05962017000300367
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54512
dc.identifier.wosWOS:000406304900012
dc.language.isoeng
dc.publisherSoc Brasileira Dermatologia
dc.relation.ispartofAnais Brasileiros De Dermatologia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAgingen
dc.subjectAntioxidantsen
dc.subjectPhenolic compoundsen
dc.subjectSkin agingen
dc.titleAn overview about oxidation in clinical practice of skin agingen
dc.typeinfo:eu-repo/semantics/article
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