Positive Association between Tinnitus and Arterial Hypertension

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dc.citation.volume7
dc.contributor.authorFigueiredo, Ricardo Rodrigues [UNIFESP]
dc.contributor.authorAzevedo, Andreia Aparecida [UNIFESP]
dc.contributor.authorPenido, Norma de Oliveira [UNIFESP]
dc.coverageLausanne
dc.date.accessioned2020-07-31T12:47:35Z
dc.date.available2020-07-31T12:47:35Z
dc.date.issued2016
dc.description.abstractIntroduction: Tinnitus is the perception of noise in the absence of an external source and is considered by most authors as a multifactorial symptom. A systematic review concerning the association of tinnitus and systemic arterial hypertension retrieved suggestions of a positive association, but the articles included failed to perform a detailed analysis on the theme. Purpose: To analyze the presence of arterial hypertension in tinnitus and non-tinnitus patients, to analyze differences between tinnitus impact and psychoacoustic measurements in hypertensive and normotensive patients, and to evaluate the association between the presence of tinnitus and the diverse antihypertensive drugs employed. Materials and methods: This includes cross-sectional transversal study, comparing two groups of subjects (144 in the study group with tinnitus and 140 in the control group without tinnitus). Clinical, demographical, audiometrical, and psychoacoustics characteristics of the subjects were compared. Results: Hypertension prevalence in tinnitus subjects was 44.4% against 31.4% in subjects without tinnitus (p = 0.024). Positive associations with tinnitus were found with hypertension treatment with angiotensin-converting enzyme (ACE) inhibitors (p = 0.006), tiazidic diuretics (p < 0.0001), potassium-sparing diuretics (p = 0.016), and calcium channels blockers (p = 0.004). Conclusion: There is an association between tinnitus and arterial hypertension. This association is particularly strong in older patients. Hypertension treatment with diuretics, ACE inhibitors, and calcium channels blockers were more prevalent in tinnitus patients, suggesting that an eventual ototoxicity of these drugs may be involved in tinnitus pathophysiology, a hypothesis that should be evaluated in further studies.en
dc.description.affiliationUniv Fed Sao Paulo, Otolaryngol, Sao Paulo, Brazil
dc.description.affiliationFac Med Valenca, Otolaryngol, Valenca, Brazil
dc.description.affiliationUnifespOtolaryngology, Universidade Federal de São Paulo, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.3389/fneur.2016.00171
dc.identifier.citationFrontiers In Neurology. Lausanne, v. 7, p. -, 2016.
dc.identifier.doi10.3389/fneur.2016.00171
dc.identifier.fileWOS000385052500001.pdf
dc.identifier.issn1664-2295
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56910
dc.identifier.wosWOS:000385052500001
dc.language.isoeng
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers In Neurology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjecttinnitusen
dc.subjectarterial hypertensionen
dc.subjecthearing lossen
dc.subjectcardiovascular diseasesen
dc.subjecthearing disordersen
dc.titlePositive Association between Tinnitus and Arterial Hypertensionen
dc.typeinfo:eu-repo/semantics/article
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