Moderate prenatal alcohol exposure alters behavior and neuroglial parameters in adolescent rats

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dc.contributor.authorBrolese, Giovana
dc.contributor.authorLunardi, Paula
dc.contributor.authorBroetto, Nubia
dc.contributor.authorEngelke, Douglas S. [UNIFESP]
dc.contributor.authorLirio, Franciane
dc.contributor.authorBatassini, Cristiane
dc.contributor.authorCarolina Tramontina, Ana
dc.contributor.authorGoncalves, Carlos-Alberto
dc.contributor.institutionUniv Fed Rio Grande do Sul
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionState Univ Rio Grande do Sul
dc.date.accessioned2016-01-24T14:37:39Z
dc.date.available2016-01-24T14:37:39Z
dc.date.issued2014-08-01
dc.description.abstractAlcohol consumption by women during gestation has become increasingly common. Although it is widely accepted that exposure to high doses of ethanol has long-lasting detrimental effects on brain development, the case for moderate doses is underappreciated, and benchmark studies have demonstrated structural and behavioral defects associated with moderate prenatal alcohol exposure in humans and animal models. This study aimed to investigate the influence of in utero exposure to moderate levels of ethanol throughout pregnancy on learning/memory, anxiety parameters and neuroglial parameters in adolescent offspring. Female rats were exposed to an experimental protocol throughout gestation up to weaning. After mating, the dams were divided into three groups and treated with only water (control), non-alcoholic beer (vehicle) or 10% (vv) beer solution (moderate prenatal alcohol exposure - MPAE). Adolescent male offspring were subjected to the plus-maze discriminative avoidance task to evaluate learning/memory and anxiety-like behavior. Hippocampi were dissected and slices were obtained for immunoquantification of GFAP, NeuN, S100B and the NMDA receptor. the MPAE group clearly presented anxiolytic-like behavior, even though they had learned how to avoid the aversive arm. S100B protein was increased in the cerebrospinal fluid (CSF) in the group treated with alcohol, and alterations in GFAP expression were also shown. This study indicates that moderate ethanol doses administered during pregnancy could induce anxiolytic-like effects, suggesting an increase in risk-taking behavior in adolescent male offspring. Furthermore, the data show the possibility that glial cells are involved in the altered behavior present after prenatal ethanol treatment. (C) 2014 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Fed Rio Grande do Sul, Basic Sci Hlth Inst, Neurosci Postgrad Program, BR-90046900 Porto Alegre, RS, Brazil
dc.description.affiliationUniv Fed Rio Grande do Sul, Basic Sci Hlth Inst, Dept Biochem, BR-90046900 Porto Alegre, RS, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, UNIFESP, Dept Neurophysiol, São Paulo, Brazil
dc.description.affiliationState Univ Rio Grande do Sul, UERGS, Porto Alegre, RS, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, UNIFESP, Dept Neurophysiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipINCT-National Institute of Science and Technology for Excitotoxicity and Neuroprotection
dc.description.sponsorshipIDINCT-National Institute of Science and Technology for Excitotoxicity and Neuroprotection: 573677/2008-5
dc.format.extent175-184
dc.identifierhttp://dx.doi.org/10.1016/j.bbr.2014.04.023
dc.identifier.citationBehavioural Brain Research. Amsterdam: Elsevier B.V., v. 269, p. 175-184, 2014.
dc.identifier.doi10.1016/j.bbr.2014.04.023
dc.identifier.issn0166-4328
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38042
dc.identifier.wosWOS:000337866400022
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBehavioural Brain Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectAlcoholen
dc.subjectAnxietyen
dc.subjectGFAPen
dc.subjectHippocampusen
dc.subjectNMDA receptoren
dc.subjectS100Ben
dc.titleModerate prenatal alcohol exposure alters behavior and neuroglial parameters in adolescent ratsen
dc.typeinfo:eu-repo/semantics/article
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