Fish Oil Supplementation Reduces Heart Levels of Interleukin-6 in Rats with Chronic Inflammation due to Epilepsy

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dc.citation.volume8]
dc.contributor.authorNejm, Mariana Bocca [UNIFESP]
dc.contributor.authorAbou Haidar, Andre [UNIFESP]
dc.contributor.authorHirata, Aparecida Emiko [UNIFESP]
dc.contributor.authorOyama, Lila Missae [UNIFESP]
dc.contributor.authorde Almeida, Antonio-Carlos Guimaraes
dc.contributor.authorCysneiros, Roberta Monterazzo
dc.contributor.authorCavalheiro, Esper Abrao [UNIFESP]
dc.contributor.authorScorza, Carla Alessandra [UNIFESP]
dc.contributor.authorScorza, Fulvio Alexandre [UNIFESP]
dc.coverageLausanne
dc.date.accessioned2020-06-26T16:30:37Z
dc.date.available2020-06-26T16:30:37Z
dc.date.issued2017
dc.description.abstractSudden unexpected death in epilepsy (SUDEP) is a major cause of premature death related to epilepsy. The causes of SUDEP remain unknown, but cardiac arrhythmias and asphyxia have been suggested as a major mechanism of this event. Inflammation has been implicated in the pathogenesis of both epilepsy and ventricular arrhythmia, with interleukin-6 (IL-6) being recognized as a crucial orchestrator of inflammatory states. Our group previously reported that levels of IL-6 were increased in the hearts of epileptic rats. In this scenario, anti-inflammatory actions are among the beneficial effects of fish oil dietary supplementation. This investigation revealed that elevated levels of IL-6 in the heart were markedly reduced in epileptic rats that were treated in the long-term with fish oil, suggesting protective anti-inflammatory actions against dangerously high levels of IL-6. Based on these findings, our results suggest beneficial effects of long-term intake of fish oil in reducing the inflammation associated with chronic epilepsy.en
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Disciplina Neurociencia, UNIFESP, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Fisiol, UNIFESP, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Joao Del Rei UFSJ, Dept Engn Biossistemas, Sao Joao Del Rei, Brazil
dc.description.affiliationUniv Presbiteriana Mackenzie, Programa Posgrad Disturbios Desenvolvimento, Ctr Ciencias Biol & Saude, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Disciplina Neurociencia, UNIFESP, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Dept Fisiol, UNIFESP, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFAPESP
dc.description.sponsorshipCAPES
dc.description.sponsorshipCNPq
dc.description.sponsorshipFAPESP/CNPq/MCT-Instituto Nacional de Neurociencia Translacional
dc.description.sponsorshipFAPEMIG
dc.description.sponsorshipCEPID/FAPESP
dc.description.sponsorshipIDFAPESP
dc.description.sponsorshipIDCAPES
dc.description.sponsorshipIDCNPq
dc.description.sponsorshipIDFAPESP/CNPq/MCT-Instituto Nacional de Neurociencia Translacional
dc.description.sponsorshipIDFAPEMIG
dc.description.sponsorshipIDCEPID/FAPESP
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.3389/fneur.2017.00263]
dc.identifier.citationFrontiers In Neurology. Lausanne, v. 8, p. -, 2017.
dc.identifier.doi10.3389/fneur.2017.00263
dc.identifier.fileWOS000403389100002.pdf
dc.identifier.issn1664-2295
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53663
dc.identifier.wosWOS:000403389100002
dc.language.isoeng
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers In Neurology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectepilepsyen
dc.subjectsudden unexpected death in epilepsyen
dc.subjectinflammationen
dc.subjecthearten
dc.subjectinterleukin-6en
dc.subjectfish oilen
dc.titleFish Oil Supplementation Reduces Heart Levels of Interleukin-6 in Rats with Chronic Inflammation due to Epilepsyen
dc.typeinfo:eu-repo/semantics/article
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