Placental transfer of naturally acquired, maternal cytomegalovirus antibodies in term and preterm neonates

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dc.contributor.authorMussi-Pinhata, M. M.
dc.contributor.authorPinto, PCG
dc.contributor.authorYamamoto, A. Y.
dc.contributor.authorBerencsi, K.
dc.contributor.authorSouza, CBS de
dc.contributor.authorAndrea, M.
dc.contributor.authorDuarte, G.
dc.contributor.authorJorge, S. M.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionWistar Inst Anat & Biol
dc.date.accessioned2016-01-24T12:33:42Z
dc.date.available2016-01-24T12:33:42Z
dc.date.issued2003-02-01
dc.description.abstractMaternal antibodies may protect the fetus and neonate against severe forms of CMV-caused disease, therefore this study investigated the efficiency-of the placental transfer of naturally acquired, maternal total anti-cytomegalovirus (CMV) IgG and neutralizing antibodies at different gestational ages. the study was conducted on 182 healthy CMV-seropositive Brazilian mothers and their 196 infants who were not infected congenitally with CMV, as determined by CMV detection in urine. the study groups were composed of 44 infants aged 28-30 weeks; 51 infants aged 31-33 weeks; 62 infants aged 3436 weeks, and 39 infants of gestational age greater than or equal to37 weeks. Quantitative detection of total CMV IgG was carried out using EIA and virus neutralizing titers were determined by a microneutralization assay in sera from mothers and infants. CMV IgG levels and neutralizing titers of the infants correlated with maternal levels (r = 0.873 and r = 0.841, respectively). the efficiency of placental transfer of these antibodies was enhanced significantly as gestation progressed until 3436 weeks, when values similar to those of fullterm infants (90-100%) were found. Transfer ratios were significantly higher for neutralizing compared to total CMV IgG antibodies at gestational age 31-33 weeks (100% vs. 84%, respectively) and at gestational age 28-30 weeks (75% vs. 60%, respectively). We conclude that placental transfer of naturally acquired maternal CMV neutralizing and total CMV IgG antibodies are similarly efficient above 34 weeks of gestational age. At less than 34 weeks of gestational age, transfer of neutralizing antibodies may be favored and these antibodies reach the neonatal serum of 99% of these premature infants.en
dc.description.affiliationUniv São Paulo, Dept Pediat, Sch Med Ribeirao Preto, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Obstet & Gynecol, Sch Med Ribeirao Preto, São Paulo, Brazil
dc.description.affiliationWistar Inst Anat & Biol, Philadelphia, PA 19104 USA
dc.description.sourceWeb of Science
dc.format.extent232-239
dc.identifierhttp://dx.doi.org/10.1002/jmv.10271
dc.identifier.citationJournal of Medical Virology. New York: Wiley-liss, v. 69, n. 2, p. 232-239, 2003.
dc.identifier.doi10.1002/jmv.10271
dc.identifier.issn0146-6615
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/27126
dc.identifier.wosWOS:000180188300011
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Medical Virology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectmaternally-acquired immunityen
dc.subjectneutralizing antibodiesen
dc.subjectIgG antibodiesen
dc.titlePlacental transfer of naturally acquired, maternal cytomegalovirus antibodies in term and preterm neonatesen
dc.typeinfo:eu-repo/semantics/article
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