Importance of glycinergic and glutamatergic synapses within the rostral ventrolateral medulla for blood pressure regulation in conscious rats

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dc.contributor.authorAraujo, G. C.
dc.contributor.authorLopes, Oswaldo Ubriaco [UNIFESP]
dc.contributor.authorCampos, Ruy Ribeiro [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T17:38:26Z
dc.date.available2018-06-15T17:38:26Z
dc.date.issued1999-10-01
dc.description.abstractIn this study we used a method that permits bilateral or unilateral microinjections of drugs into the rostral ventrolateral medulla (RVLM) of conscious, freely moving rats. There is only limited information about how sympathetic vasomotor tone is maintained by premotor RVLM neurons in conscious animals, It has long been known that glycine microinjection into the RVLM region leads to a decrease in blood pressure (BP) in anesthetized animals. In the present study we show that both unilateral and bilateral microinjection of glycine at the same dose used for anesthetized rats (50 nmol, 50 nL) into the RVLM increases BP-in conscious animals. A similar response was also observed when the excitatory amino acid L-glutamate was microinjected into the RVLM. The microinjection of kynurenic acid into the RVLM did not change the basal level of BP but blocked the increase in BP after glycine or glutamate microinjection. A decrease in BP was only observed when low doses of glycine were used (1 to 10 nmol). We conclude that, in conscious animals, the hypertension occurring in response to high doses of glycine into the RVLM is dependent on glutamatergic synapses within the RVLM. A decrease in BP observed when low doses of glycine were used shows that in conscious animals, the RVLM, in association with other premotor neurons, is probably responsible for the maintenance of sympathetic vasomotor tone, because glycine is less effective In decreasing BP under these circumstances than in anesthetized animals.en
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Fisiol, BR-04023060 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Dept Fisiol, BR-04023060 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent752-755
dc.identifierhttps://doi.org/10.1161/01.HYP.34.4.752
dc.identifier.citationHypertension. Philadelphia: Lippincott Williams & Wilkins, v. 34, n. 4, p. 752-755, 1999.
dc.identifier.doi10.1161/01.HYP.34.4.752
dc.identifier.issn0194-911X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43885
dc.identifier.wosWOS:000083486500009
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofHypertension
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectvasomotor toneen
dc.subjectventrolateral medullaen
dc.subjectglycineen
dc.subjecthypertension, experimentalen
dc.subjectratsen
dc.titleImportance of glycinergic and glutamatergic synapses within the rostral ventrolateral medulla for blood pressure regulation in conscious ratsen
dc.typeinfo:eu-repo/semantics/article
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