Prior exercise training does not prevent acute cardiac alterations after myocardial infarction in female rats

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dc.contributor.authorVeiga, Eduardo C. A. [UNIFESP]
dc.contributor.authorAntonio, Ednei Luiz [UNIFESP]
dc.contributor.authorBocalini, Danilo S. [UNIFESP]
dc.contributor.authorMurad, Neif
dc.contributor.authorAbreu, Luiz Carlos de
dc.contributor.authorTucci, Paulo José Ferreira [UNIFESP]
dc.contributor.authorSato, Monica A.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionFaculdade de Medicina do ABC Cardiology division Department of Medicine
dc.contributor.institutionFaculdade de Medicina do ABC Department of Physiology
dc.date.accessioned2015-06-14T13:42:52Z
dc.date.available2015-06-14T13:42:52Z
dc.date.issued2011-01-01
dc.description.abstractOBJECTIVE: This study aimed to investigate whether previous exercise training could prevent or attenuate acute cardiac alterations after myocardial infarction. METHODS: Female rats were submitted to swim training (1 h/day; 5 days/week) or allowed to remain sedentary for 8 weeks. Afterwards, they were randomly assigned to left coronary artery occlusion or sham surgery. After this procedure, the rats remained sedentary for one week until euthanasia. Cardiac structural and functional analyses were performed using Doppler echocardiography. The rats that had a moderate or large infarct size were included in the evaluations. The data (mean + SEM) were analyzed using a two-way ANOVA model followed byTukey's post-hoc test. RESULTS: After the surgery, no significant difference between the exercise and sedentary groups was observed in the left ventricular infarct sizes (34.58 + 3.04 vs. 37.59 + 3.07). In another group of rats evaluated with Evans blue 1 h after myocardial infarction, no siginificant difference in the area at risk was observed between the exercised and sedentary rats (49.73 + 1.52 vs. 45.48 + 3.49). The changes in the left ventricular fractional areas for the exercised and sedentary myocardial infarction groups (36 + 2% and 39 + 3%, respectively) were smaller than those for the exercise sham surgery (ES, 67+1%) and sedentary sham surgery (SS, 69 + 2%) groups. The E/A was higher in the sedentary myocardial infarction (4.4 + 0.3) and exercised myocardial infarction (5.5 + 0.3) rats than in the SS (2.4 + 0.1) and ES (2.2 + 0.1) rats. CONCLUSION: Previous swim training of female rats does not attenuate systolic and diastolic function alterations after myocardial infarction induced by left coronary artery occlusion, suggesting that cardioprotection cannot be provided by exercise training in this experimental model.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Cardiology division
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Department of Physiology
dc.description.affiliationFaculdade de Medicina do ABC Cardiology division Department of Medicine
dc.description.affiliationFaculdade de Medicina do ABC Department of Physiology
dc.description.affiliationUnifespUNIFESP, EPM, Cardiology division
dc.description.affiliationUnifespUNIFESP, EPM, Department of Physiology
dc.description.sourceSciELO
dc.format.extent889-893
dc.identifierhttp://dx.doi.org/10.1590/S1807-59322011000500028
dc.identifier.citationClinics. Faculdade de Medicina / USP, v. 66, n. 5, p. 889-893, 2011.
dc.identifier.doi10.1590/S1807-59322011000500028
dc.identifier.fileS1807-59322011000500028.pdf
dc.identifier.issn1807-5932
dc.identifier.scieloS1807-59322011000500028
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/6256
dc.identifier.wosWOS:000293122900028
dc.language.isoeng
dc.publisherFaculdade de Medicina / USP
dc.relation.ispartofClinics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPhysical Exerciseen
dc.subjectMyocardial Infarctionen
dc.subjectRemodelingen
dc.subjectVentricular Functionen
dc.subjectEchocardiographyen
dc.titlePrior exercise training does not prevent acute cardiac alterations after myocardial infarction in female ratsen
dc.typeinfo:eu-repo/semantics/article
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