Improved glycemic control by acarbose therapy in hypertensive diabetic patients: effects on blood pressure and hormonal parameters

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dc.contributor.authorRosenbaum, Paulo [UNIFESP]
dc.contributor.authorPeres, Ricardo Botticini [UNIFESP]
dc.contributor.authorZanella, Maria Teresa [UNIFESP]
dc.contributor.authorFerreira, Sandra Roberta Gouvea [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:29:46Z
dc.date.available2015-06-14T13:29:46Z
dc.date.issued2002-08-01
dc.description.abstractA double-blind, randomized, placebo-controlled study was carried out on 44 hypertensive type 2 diabetic subjects previously treated by diet associated or not with sulfonylurea to assess the effects of acarbose-induced glycemic control on blood pressure (BP) and hormonal parameters. Before randomization and after a 22-week treatment period (100 to 300 mg/day), the subjects were submitted to a standard meal test and to 24-h ambulatory BP monitoring (ABPM) and had plasma glucose, glycosylated hemoglobin, lipid profile, insulin, proinsulin and leptin levels determined. Weight loss was found only in the acarbose-treated group (75.1 ± 11.6 to 73.1 ± 11.6 kg, P<0.01). Glycosylated hemoglobin decreased only in the acarbose group (6.4 ± 1.7 to 5.6 ± 1.9%, P<0.05). Fasting proinsulin decreased only in the acarbose group (23.4 ± 19.3 to 14.3 ± 13.6 pmol/l, P<0.05), while leptin decreased in both (placebo group: 26.3 ± 6.1 to 23.3 ± 9.4 and acarbose group: 25.0 ± 5.5 to 22.7 ± 7.9 ng/ml, P<0.05). When the subset of acarbose-treated patients who improved glycemic control was considered, significant reductions in diurnal systolic, diastolic and mean BP (102.3 ± 6.0 to 99.0 ± 6.6 mmHg, P<0.05) were found. Acarbose monotherapy or combined with sulfonylurea was effective in improving glycemic control in hypertensive diabetic patients. Acarbose-induced improvement in metabolic control may reduce BP in these patients. Our data did not suggest a direct action of acarbose on insulin resistance or leptin levels.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Divisão de Endocrinologia
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Divisão de Nefrologia
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Departamento de Medicina Preventiva
dc.description.affiliationUnifespUNIFESP, Divisão de Endocrinologia
dc.description.affiliationUnifespUNIFESP, Divisão de Nefrologia
dc.description.affiliationUnifespUNIFESP, Depto. de Medicina Preventiva
dc.description.sourceSciELO
dc.format.extent877-884
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2002000800004
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 35, n. 8, p. 877-884, 2002.
dc.identifier.doi10.1590/S0100-879X2002000800004
dc.identifier.fileS0100-879X2002000800004.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2002000800004
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/1499
dc.identifier.wosWOS:000179079400004
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectType 2 diabetes mellitusen
dc.subjectAcarboseen
dc.subjectHypertensionen
dc.subjectHyperinsulinemiaen
dc.titleImproved glycemic control by acarbose therapy in hypertensive diabetic patients: effects on blood pressure and hormonal parametersen
dc.typeinfo:eu-repo/semantics/article
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