The role of IL-6, IL-8 and MCP-1 and their promoter polymorphisms IL-6-174GC, IL-8-251AT and MCP-1-2518AG in the risk of venous thromboembolism: A case-control study

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dc.contributor.authorMatos, Marinez Farana [UNIFESP]
dc.contributor.authorLourenco, Dayse M. [UNIFESP]
dc.contributor.authorOrikaza, Cristina M. [UNIFESP]
dc.contributor.authorBajerl, Joao A. H. [UNIFESP]
dc.contributor.authorNoguti, Maria A. E. [UNIFESP]
dc.contributor.authorMorelli, Vania M. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:17:10Z
dc.date.available2016-01-24T14:17:10Z
dc.date.issued2011-09-01
dc.description.abstractIntroduction: Cytokines increased the risk of venous thromboembolism (VTE) in some case-control studies, but not in a prospective study. Data concerning the role of cytokines in the risk of VTE are limited. We examined in a case-control study the association of VTE and levels of interleukin (IL)-6, IL-8 and monocyte chemotactic protein-1 (MCP-1) and assessed whether promoter polymorphisms (IL-6 -174GC, IL-8 -251AT, MCP-1 -2518AG) would affect the thrombotic risk and cytokine levels.Materials and methods: the study included 119 patients (94 women) with a first event of VTE aged between 18-60 years, and 126 healthy controls (100 women) matched for age (+/- 5 years). Blood was collected >7 months after the thrombotic event. Odds ratios (ORs) were calculated per increase of cytokines levels by 1 pg/mL.Results: ORs adjusted for age and sex were 1.520 [95% Confidence Interval (CI) 1.177 - 1.962] for IL-6, 1.095 (95% CI 1.002 - 1.196) for IL-8 and 1.000 (0.988 - 1.012) for MCP-1. With additional adjustment for ethnic composition, body mass index (BMI) and high sensitive C-reactive protein (hs-CRP), risk estimates remained significant for IL-6 and became of borderline statistical significance for IL-8. Polymorphisms did not influence the thrombotic risk and the cytokine levels in study participants.Conclusion: VTE was associated with IL-6 and IL-8 levels, and for IL-6 this association was independent of BMI and hs-CRP. Thus far, a causal relationship between inflammation and VTE remains to be clarified and more prospective data are warranted. (C) 2011 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Hematol & Hemotherapy Serv, UNIFESP, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Hematol & Hemotherapy Serv, UNIFESP, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2005/56799-0
dc.format.extent216-220
dc.identifierhttp://dx.doi.org/10.1016/j.thromres.2011.04.016
dc.identifier.citationThrombosis Research. Oxford: Pergamon-Elsevier B.V., v. 128, n. 3, p. 216-220, 2011.
dc.identifier.doi10.1016/j.thromres.2011.04.016
dc.identifier.issn0049-3848
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34017
dc.identifier.wosWOS:000294000100004
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofThrombosis Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectInterleukinen
dc.subjectPolymorphismen
dc.subjectRisk factoren
dc.subjectVenous thromboembolismen
dc.titleThe role of IL-6, IL-8 and MCP-1 and their promoter polymorphisms IL-6-174GC, IL-8-251AT and MCP-1-2518AG in the risk of venous thromboembolism: A case-control studyen
dc.typeinfo:eu-repo/semantics/article
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