Androgen deprivation from pre-puberty to peripuberty interferes in proteins expression in pubertal and adult rat epididymis

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dc.contributor.authorPerobelli, Juliana Elaine
dc.contributor.authorPatrão, Marilia Tavares Coutinho da Costa [UNIFESP]
dc.contributor.authorFernandez, Carla Dal Bianco
dc.contributor.authorSanabria, Marciana
dc.contributor.authorKlinefelter, Gary R.
dc.contributor.authorAvellar, Maria Christina Werneck [UNIFESP]
dc.contributor.authorKempinas, Wilma De Grava
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUNESP Univ Estadual Paulista
dc.contributor.institutionUnited States Environm Protect Agcy
dc.date.accessioned2016-01-24T14:31:57Z
dc.date.available2016-01-24T14:31:57Z
dc.date.issued2013-07-01
dc.description.abstractFew studies have focused on experimental testosterone deprivation in immature animals. Therefore, this study used sexually immature rats aiming to evaluate the testes and epididymis histology and proteins expression in these organs on PND50 and 75, after premature antiandrogen exposure, from PND21 to 44. Although the androgen deprivation from pre-puberty up to peripuberty did not alter the histological organization of the testes and epididymis either at puberty or at adulthood, the treatment impaired the expression of specific proteins in epididymal tissue at puberty and adulthood (androgen receptor, calmodulin, Rab11A). These changes may be related to impaired epididymal function, sperm quality and fertility capacity as observed in a previous study. Further studies are necessary to better investigate the molecular mechanisms involved in the impairment on reproductive competence of male rats after precocious hormonal injury. (c) 2013 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniv Campinas UNICAMP, Inst Biol, Grad Program Cellular & Struct Biol, Campinas, SP, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Inst Biosci, Dept Morphol, Botucatu, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, INFAR, Sect Expt Endocrinol,Dept Pharmacol, São Paulo, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Inst Biosci, Grad Program Gen & Appl Biol, São Paulo, Brazil
dc.description.affiliationUnited States Environm Protect Agcy, Toxicol Assessment Div, Natl Hlth & Environm Effects Res Lab, Reprod Toxicol Branch, Washington, DC USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, INFAR, Sect Expt Endocrinol,Dept Pharmacol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt
dc.description.sponsorshipIDFAPESP: 07/59079-4pt
dc.description.sponsorshipIDCNPq: 501339/2010-8pt
dc.description.sponsorshipIDCNPq: 304958/2009-3pt
dc.format.extent65-71
dc.identifierhttps://dx.doi.org/10.1016/j.reprotox.2013.03.004
dc.identifier.citationReproductive Toxicology. Oxford: Pergamon-Elsevier B.V., v. 38, p. 65-71, 2013.
dc.identifier.doi10.1016/j.reprotox.2013.03.004
dc.identifier.issn0890-6238
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/36500
dc.identifier.wosWOS:000319535200007
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofReproductive Toxicology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectAntiandrogenen
dc.subjectRaten
dc.subjectEpididymisen
dc.subjectPeripubertyen
dc.subjectProtein expressionen
dc.titleAndrogen deprivation from pre-puberty to peripuberty interferes in proteins expression in pubertal and adult rat epididymisen
dc.typeinfo:eu-repo/semantics/article
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