Do the radiological criteria with the use of risk factors impact the forecasting of abdominal neuroblastic tumor resection in children?
dc.citation.issue | 2 | |
dc.citation.volume | 30 | |
dc.contributor.author | Soares Penazzi, Ana Claudia [UNIFESP] | |
dc.contributor.author | Tostes, Vivian Siqueira | |
dc.contributor.author | Barros Duarte, Alexandre Alberto [UNIFESP] | |
dc.contributor.author | Lederman, Henrique Manoel [UNIFESP] | |
dc.contributor.author | Monteiro Caran, Eliana Maria [UNIFESP] | |
dc.contributor.author | Vieira Abib, Simone de Campos [UNIFESP] | |
dc.coverage | Sao Paulo Sp | |
dc.date.accessioned | 2020-07-17T14:02:18Z | |
dc.date.available | 2020-07-17T14:02:18Z | |
dc.date.issued | 2017 | |
dc.description.abstract | Background: The treatment of neuroblastoma is dependent on exquisite staging | en |
dc.description.abstract | is performed postoperatively and is dependent on the surgeon's expertise. The use of risk factors through imaging on diagnosis appears as predictive of resectability, complications and homogeneity in staging. Aim: To evaluate the traditional resectability criteria with the risk factors for resectability, through the radiological images, in two moments: on diagnosis and in pre-surgical phase. Were analyzed the resectability, surgical complications and relapse rate. Methods: Retrospective study of 27 children with abdominal and pelvic neuroblastoma stage 3 and 4, with tomography and/or resonance on the diagnosis and pre-surgical, identifying the presence of risk factors. Results: The mean age of the children was 2.5 years at diagnosis, where 55.6% were older than 18 months, 51.9% were girls and 66.7% were in stage 4. There was concordance on resectability of the tumor by both methods (INSS and IDRFs) at both moments of the evaluation, at diagnosis (p=0.007) and post-chemotherapy (p=0.019) | en |
dc.description.abstract | In this way, all resectable patients by IDRFs in the post-chemotherapy had complete resection, and the unresectable ones, 87.5% incomplete. There was remission in 77.8%, 18.5% relapsed and 33.3% died. Conclusions: Resectability was similar in both methods at both pre-surgical and preoperative chemotherapy | en |
dc.description.abstract | preoperative chemotherapy increased resectability and decreased number of risk factors, where the presence of at least one IDRF was associated with incomplete resections and surgical complications | en |
dc.description.abstract | relapses were irrelevant. | en |
dc.description.abstract | Racional: O tratamento do neuroblastoma é dependente de estadiamento primoroso, realizado no pós-cirúrgico e dependente da expertise do cirurgião. O uso de fatores de risco através da imagem ao diagnóstico surge como preditivo de ressecabilidade, complicações e homogeneidade no estadiamento. Objetivos: Avaliar o critério de ressecabilidade tradicional com os fatores de risco para ressecabilidade, através das imagens radiológicas, em dois momentos no diagnóstico e no pré-cirúrgico analisando a ressecabilidade, complicações cirúrgicas e índice de recidiva. Métodos: Estudo retrospectivo em 27 crianças com neuroblastoma estádios 3 e 4 em abdome e pelve, e com tomografia e/ou ressonância no diagnóstico e pré-cirúrgico, identificando-se a presença de fatores de risco. Resultados: A idade média das crianças foi de 2,5 anos ao diagnóstico, onde 55,6% estavam acima dos 18 meses, 51,9% eram meninas e 66,7% tinham estádio 4. Houve concordância da ressecabilidade do tumor pelos dois métodos avaliados (INSS e IDRFs) e em ambos os momentos da avaliação, ao diagnóstico (p=0,007) e pós-quimioterapia (p=0,019). Desta forma todos pacientes ressecáveis por IDRFs no pós-quimioterapia tiveram ressecção completa; já nos irressecáveis, 87,5% tiveram ressecção incompleta. Houve remissão em 77,8%, 18,5% recaíram e 33,3% morreram. Conclusões: A ressecabilidade foi semelhante em ambos os métodos tanto no diagnóstico como no pré-cirúrgico. A quimioterapia pré-operatória aumentou a ressecabilidade e diminuição do número de fatores de risco, onde a presença de ao menos um IDRF associou-se às ressecções incompletas e complicações cirúrgicas. As recidivas foram irrelevantes | pt |
dc.description.affiliation | Fed Univ Sao Paulo UNIFESP, Postgrad Program Interdisciplinary Surg Sci, Sao Paulo, SP, Brazil | |
dc.description.affiliation | Fed Univ Sao Paulo UNIFESP, Pediat Oncol Inst, Support Grp Adolescent & Child Canc IOP GRAACC, Sao Paulo, SP, Brazil | |
dc.description.affiliationUnifesp | Fed Univ Sao Paulo UNIFESP, Postgrad Program Interdisciplinary Surg Sci, Sao Paulo, SP, Brazil | |
dc.description.affiliationUnifesp | Fed Univ Sao Paulo UNIFESP, Pediat Oncol Inst, Support Grp Adolescent & Child Canc IOP GRAACC, Sao Paulo, SP, Brazil | |
dc.description.source | Web of Science | |
dc.format.extent | 88-92 | |
dc.identifier | http://dx.doi.org/10.1590/0102-6720201700020003 | |
dc.identifier.citation | Abcd-Arquivos Brasileiros De Cirurgia Digestiva-Brazilian Archives Of Digestive Surgery. Sao Paulo Sp, v. 30, n. 2, p. 88-92, 2017. | |
dc.identifier.doi | 10.1590/0102-6720201700020003 | |
dc.identifier.file | S0102-67202017000200088-en.pdf | |
dc.identifier.file | S0102-67202017000200088-pt.pdf | |
dc.identifier.issn | 0102-6720 | |
dc.identifier.scielo | S0102-67202017000200088 | |
dc.identifier.uri | https://repositorio.unifesp.br/handle/11600/54730 | |
dc.identifier.wos | WOS:000416611600003 | |
dc.language.iso | eng | |
dc.language.iso | por | |
dc.publisher | Colegio Brasileiro Cirurgia Digestiva-Cbcd | |
dc.relation.ispartof | Abcd-Arquivos Brasileiros De Cirurgia Digestiva-Brazilian Archives Of Digestive Surgery | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Neuroblastoma | en |
dc.subject | Neoplasm staging | en |
dc.subject | Risk factors | en |
dc.subject | Neuroblastoma | pt |
dc.subject | Estadiamento de neoplasias | pt |
dc.subject | Fatores de risco | pt |
dc.title | Do the radiological criteria with the use of risk factors impact the forecasting of abdominal neuroblastic tumor resection in children? | en |
dc.title.alternative | Critérios radiológicos impactam a previsão de ressecabilidade em neuroblastomas abdominais na criança com o uso de fatores de risco? | pt |
dc.type | info:eu-repo/semantics/article |