Commissural nucleus of the solitary tract is important for cardiovascular responses to caudal pressor area activation

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dc.contributor.authorTakakura, Ana Carolina
dc.contributor.authorMoreira, Thiago Santos
dc.contributor.authorMenani, Jose V.
dc.contributor.authorCampos, Ruy Ribeiro
dc.contributor.authorColombaria, Eduardo
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Estadual Paulista UNESP
dc.date.accessioned2016-01-24T13:48:59Z
dc.date.available2016-01-24T13:48:59Z
dc.date.issued2007-08-03
dc.description.abstractThe nucleus of the solitary tract (NTS) is the site of the first synapse of cardiovascular afferent fibers in the central nervous system. Important mechanisms for cardiovascular regulation are also present in the caudal pressor area (CPA) localized at the caudal end of the ventrolateral medulla. in the present study we sought to investigate the role of the commissural subnucleus of the NTS (commNTS) on pressor and tachycardic responses induced by L-glutamate injected into the CPA. Male Holtzman rats (n=8 rats/group) anesthetized with urethane (1.2 g/kg of body weight, iv) received injections of the GABAA receptor agonist muscimol into the commNTS. Unilateral injection of L-glutamate (10 nmol/ 100 nL) into the CPA increased mean arterial pressure (MAP, 31 4 mm Hg, vs. saline: 3 +/- 2 mm Hg) and heart rate (HR, 44 8 bpm, vs. saline: 10 7 bpm). inhibition of commNTS neurons with muscimol (120 pmol/60 nL) abolished the increase in MAP (9 4 mm Hg) and HR (17 7 bpm) produced by L-glutamate into the CPA. the present results suggest that the pressor and tachycardic responses to CPA activation are dependent on commNTS mechanisms.en
dc.description.affiliationUniversidade Federal de São Paulo EPM, Dept Phys, BR-04023060 São Paulo, SP, Brazil
dc.description.affiliationUniv Estadual Paulista UNESP, Fac Odontol, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo EPM, Dept Phys, BR-04023060 São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent32-37
dc.identifierhttp://dx.doi.org/10.1016/j.brainres.2007.05.059
dc.identifier.citationBrain Research. Amsterdam: Elsevier B.V., v. 1161, p. 32-37, 2007.
dc.identifier.doi10.1016/j.brainres.2007.05.059
dc.identifier.issn0006-8993
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29955
dc.identifier.wosWOS:000248891300004
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectventrolateral medullaen
dc.subjectsympatheticen
dc.subjecthypertensionen
dc.subjectexcitatory amino aciden
dc.subjectMuscimolen
dc.subjectNTSen
dc.subjectCPAen
dc.titleCommissural nucleus of the solitary tract is important for cardiovascular responses to caudal pressor area activationen
dc.typeinfo:eu-repo/semantics/article
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