Unraveling snake venom complexity with 'omics' approaches: Challenges and perspectives

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dc.contributor.authorZelanis, Andre [UNIFESP]
dc.contributor.authorTashima, Alexandre Keiji [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:37:49Z
dc.date.available2016-01-24T14:37:49Z
dc.date.issued2014-09-01
dc.description.abstractThe study of snake venom proteomes (venomics) has been experiencing a burst of reports, however the comprehensive knowledge of the dynamic range of proteins present within a single venom, the set of post-translational modifications (PTMs) as well as the lack of a comprehensive database related to venom proteins are among the main challenges in venomics research. the phenotypic plasticity in snake venom proteomes together with their inherent toxin proteoform diversity, points out to the use of integrative analysis in order to better understand their actual complexity. in this regard, such a systems venomics task should encompass the integration of data from transcriptomic and proteomic studies (specially the venom gland proteome), the identification of biological PTMs, and the estimation of artifactual proteomes and peptidomes generated by sample handling procedures. (C) 2014 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ciencia & Tecnol, ICT UNIFESP, BR-12231280 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Bioquim, BR-12231280 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ciencia & Tecnol, ICT UNIFESP, BR-12231280 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Bioquim, BR-12231280 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent131-134
dc.identifierhttp://dx.doi.org/10.1016/j.toxicon.2014.05.011
dc.identifier.citationToxicon. Oxford: Pergamon-Elsevier B.V., v. 87, n. 1, p. 131-134, 2014.
dc.identifier.doi10.1016/j.toxicon.2014.05.011
dc.identifier.issn0041-0101
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38177
dc.identifier.wosWOS:000339145900016
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofToxicon
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectSnake venomen
dc.subjectVenomicsen
dc.subjectProteomeen
dc.subjectPeptidomeen
dc.subjectSystems venomicsen
dc.titleUnraveling snake venom complexity with 'omics' approaches: Challenges and perspectivesen
dc.typeinfo:eu-repo/semantics/article
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