Cryopreserved adipose tissue-derived stromal/stem cells: potential for applications in clinic and therapy

Página do item simplificado
dc.contributor.authorZanata, Fabiana [UNIFESP]
dc.contributor.authorShaik, Shahensha
dc.contributor.authorDevireddy, Ram V.
dc.contributor.authorWu, Xiying
dc.contributor.authorFerreira, Lydia Masako [UNIFESP]
dc.contributor.authorGimble, Jeffrey M.
dc.date.accessioned2019-01-21T10:29:30Z
dc.date.available2019-01-21T10:29:30Z
dc.date.issued2016
dc.description.abstractAdipose-Derived Stromal/Stem Cells (ASC) have considerable potential for regenerative medicine due to their abilities to proliferate, differentiate into multiple cell lineages, high cell yield, relative ease of acquisition, and almost no ethical concerns since they are derived from adult tissue. Storage of ASC by cryopreservation has been well described that maintains high cell yield and viability, stable immunophenotype, and robust differentiation potential post-thaw. This ability is crucial for banking research and for clinical therapeutic purposes that avoid the morbidity related to repetitive liposuction tissue harvests. ASC secrete various biomolecules such as cytokines which are reported to have immunomodulatory properties and therapeutic potential to reverse symptoms of multiple degenerative diseases/disorders. Nevertheless, safety regarding the use of these cells clinically is still under investigation. This chapter focuses on the different aspects of cryopreserved ASC and the methods to evaluate their functionality for future clinical use.en
dc.description.affiliationFederal University of Sao Paulo - Sao Paulo, Brazil
dc.description.affiliationCenter for Stem Cell Research & Regenerative Medicine Tulane University - New Orleans, USA
dc.description.affiliationDepartment of Mechanical EngineeringLouisiana State University Baton Rouge 70803 USA
dc.description.affiliationLa Cell LLC, New Orleans BioInnovation Center New Orleans, Suite 304,1441 Canal St, New Orleans, LA 70112 USA
dc.description.affiliationUnifespFederal University of Sao Paulo - Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent137-146
dc.identifierhttps://doi.org/10.1007/978-3-319-45457-3_11
dc.identifier.citationBiobanking And Cryopreservation Of Stem Cells. Cham, v. 951, p. 137-146, 2016.
dc.identifier.doi10.1007/978-3-319-45457-3_11
dc.identifier.issn0065-2598
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/49247
dc.identifier.wosWOS:000400699700012
dc.language.isoeng
dc.publisherFac Latinoamericana Ciencias Sociales-Flacso, Ecuador
dc.relation.ispartofBiobanking And Cryopreservation Of Stem Cells
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectAdipose-Derived Stromal/Stem Cellsen
dc.subjectRegenerative Medicineen
dc.subjectAdipose Tissueen
dc.subjectHuman Cellsen
dc.subjectCell Differentiationen
dc.subjectImmunophenotypeen
dc.subjectCryopreservationen
dc.subjectClinical TrialsAdult Stem-Cellsen
dc.subjectExperimental Autoimmune Encephalomyelitisen
dc.subjectInternational-Societyen
dc.subjectCrohns Fistulaen
dc.subjectAutologous Transplantationen
dc.subjectAssisted Lipotransferen
dc.subjectStem/Stromal Cellsen
dc.subjectPosition Statementen
dc.subjectCalvarial Defectsen
dc.subjectVascular Fractionen
dc.titleCryopreserved adipose tissue-derived stromal/stem cells: potential for applications in clinic and therapyen
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/bookPart
Arquivos
Coleções
EPM - Outras produções