A preoperative and intraoperative scoring system to predict nodal metastasis in endometrial cancer

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dc.citation.issue1
dc.citation.volume137
dc.contributor.authorTeixeira, Andressa M. S. [UNIFESP]
dc.contributor.authorRibeiro, Reitan
dc.contributor.authorSchmeler, Kathleen M.
dc.contributor.authorHerzog, Thomas J.
dc.contributor.authorNicolau, Sergio M. [UNIFESP]
dc.contributor.authorMarques, Renato M. [UNIFESP]
dc.coverageHoboken
dc.date.accessioned2020-07-17T14:02:31Z
dc.date.available2020-07-17T14:02:31Z
dc.date.issued2017
dc.description.abstractObjective: To develop a scoring system that guides surgical decision-making regarding the need to perform lymphadenectomy. Methods: A retrospective study was performed of patients who underwent complete surgical staging of endometrial cancer between 2003 and 2014 at three centers in Brazil. Preoperative and intraoperative risk factors were used to develop a scoring system to predict lymph node metastasis. Results: Among 329 patients included, 71 (21.6%) had positive lymph nodes and 259 (78.4%) had negative lymph nodes. The characteristics associated with nodal metastasis in univariate analysis included the level of cancer antigen 125 (P<0.001), preoperative histological grade (P<0.001), endometrial thickness (P=0.012), and pathologic features including tumor size (P<0.001), tumor extension (P<0.001), and lower uterine segment involvement (P<0.001). On multivariate logistic regression analysis, tumor grade, tumor extension, and lower uterine segment involvement remained significantly associated. The resulting scoring system showed good accuracy as demonstrated by an area under the receiver operating characteristic curve of 0.858 (95% confidence interval 0.804-0.913). Conclusion: A highly accurate scoring system for the prediction of lymph node metastasis was developed on the basis of three preoperative and intraoperative risk factors. After validation, this model could greatly aid clinicians in the surgical management of endometrial cancer.en
dc.description.affiliationUniv Fed Sao Paulo, Gynecol Dept, Sao Paulo, Brazil
dc.description.affiliationHosp Erasto Gaertner, Surg Oncol Dept, Curitiba, Parana, Brazil
dc.description.affiliationUniv Texas MD Anderson Canc Ctr, Dept Gynecol Oncol, Houston, TX 77030 USA
dc.description.affiliationUniv Cincinnati, Dept Obstet & Gynecol, Cincinnati, OH USA
dc.description.affiliationHosp Israelita Albert Einstein, Oncol Dept, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Gynecol Dept, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordination for the Improvement of Higher Education Personnel (CAPES) Foundation
dc.description.sponsorshipMinistry of Education of Brazil
dc.format.extent78-85
dc.identifierhttp://dx.doi.org/10.1002/ijgo.12103
dc.identifier.citationInternational Journal Of Gynecology & Obstetrics. Hoboken, v. 137, n. 1, p. 78-85, 2017.
dc.identifier.doi10.1002/ijgo.12103
dc.identifier.issn0020-7292
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54843
dc.identifier.wosWOS:000398814900015
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofInternational Journal Of Gynecology & Obstetrics
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectEndometrial canceren
dc.subjectLymph node metastasisen
dc.subjectLymphadenectomyen
dc.subjectScoring systemen
dc.titleA preoperative and intraoperative scoring system to predict nodal metastasis in endometrial canceren
dc.typeinfo:eu-repo/semantics/article
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