Immunoexpression of hpv 16/18 e6 and e7 oncoproteins in high-grade cervical squamous intraepithelial lesions in hiv-positive women

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dc.contributor.authorRodrigues, L. C. [UNIFESP]
dc.contributor.authorde Gois Speck, N. M. [UNIFESP]
dc.contributor.authorde Azevedo Focchi, G. R. [UNIFESP]
dc.contributor.authorSchimidt, M. A. [UNIFESP]
dc.contributor.authorMarques, R. M. [UNIFESP]
dc.contributor.authorLascasas Ribalta, J. C. [UNIFESP]
dc.date.accessioned2019-01-21T10:30:04Z
dc.date.available2019-01-21T10:30:04Z
dc.date.issued2016
dc.description.abstractThe aim of this study was to assess the immunoexpression of human papillomavirus genotypes 16 and 18 (E6 and E7) oncoproteins in cervical high-grade squamous intraepithelial lesions (HSIL) of human immunodeficiency virus (HIV)-positive women. These results were also compared to the persistence and/or recurrence of lesions after loop electrosurgical excision procedure. Cervical samples from 158 patients were divided into three groups according to the presence or absence of HSIL in women who were or were not HIV-positive. By using the tissue microarray technique, immunohistochemistry was performed to analyze the expression of HPV 16/18 E6 and E7 oncoproteins. Cervical samples from 95 HIV-positive women and 63 HIV-negative women were studied. A statistically significant difference was found in the immunoexpression of E6 and E7 oncoproteins in samples from HIV-positive women with HSIL and that of women with non-neoplastic tissue (P < 0.001). There was also a statistically significant correlation between the immunoexpression of E6 (P = 0.012) and E7 (P < 0.001) oncoproteins in lesion persistence among HIV-positive women. Within the limitations of this study, the immunoexpression of HPV 16/18 E6 and E7 oncoproteins may have prognostic value regarding lesion persistence in HIV-positive women.en
dc.description.affiliationNúcleo de Prevenção de Doenças Ginecológicas, Departamento de Ginecologia, Universidade Federal de São Paulo, São Paulo, SP, Brasil
dc.description.affiliationDepartamento de Patologia, Universidade Federal de São Paulo, São Paulo, SP, Brasil
dc.description.affiliationDisciplina de Oncologia Ginecológica, Departamento de Ginecologia, Universidade Federal de São Paulo, São Paulo, SP, Brasil
dc.description.affiliationUnifespNúcleo de Prevenção de Doenças Ginecológicas, Departamento de Ginecologia, Universidade Federal de São Paulo, São Paulo, SP, Brasil
dc.description.affiliationUnifespDepartamento de Patologia, Universidade Federal de São Paulo, São Paulo, SP, Brasil
dc.description.affiliationUnifespDisciplina de Oncologia Ginecológica, Departamento de Ginecologia, Universidade Federal de São Paulo, São Paulo, SP, Brasil
dc.description.sourceWeb of Science
dc.format.extentUNSP gmr.15017220
dc.identifierhttp://dx.doi.org/10.4238/gmr.15017220
dc.identifier.citationGenetics And Molecular Research. Ribeirao preto, v. 15, n. 1, p. UNSP gmr.15017220, 2016.
dc.identifier.doi10.4238/gmr.15017220
dc.identifier.issn1676-5680
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/49554
dc.identifier.wosWOS:000373880200024
dc.language.isoeng
dc.publisherFunpec-editora
dc.relation.ispartofGenetics And Molecular Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHuman Immunodeficiency Virusen
dc.subjectE6 Oncoproteinen
dc.subjectE7 Oncoproteinen
dc.subjectHuman Papillomavirus 16/18en
dc.subjectHigh-Grade Squamous Intraepithelial LesionsHuman-Papillomavirusen
dc.subjectTissue Microarraysen
dc.subjectInfectionen
dc.subjectDysplasiaen
dc.subjectNeoplasiaen
dc.subjectRisken
dc.titleImmunoexpression of hpv 16/18 e6 and e7 oncoproteins in high-grade cervical squamous intraepithelial lesions in hiv-positive womenen
dc.typeinfo:eu-repo/semantics/article
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