Depression and anxiety in adults with sickle cell disease: the PiSCES project

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dc.contributor.authorLevenson, James L.
dc.contributor.authorMcClish, Donna K.
dc.contributor.authorDahman, Bassam A.
dc.contributor.authorBovbjerg, Vjktor E.
dc.contributor.authorCitero, Vanessa de A. [UNIFESP]
dc.contributor.authorPenberthy, Lynne T.
dc.contributor.authorAisiku, Imoigele P.
dc.contributor.authorRoberts, John D.
dc.contributor.authorRoseff, Susan D.
dc.contributor.authorSmith, Wally R.
dc.contributor.institutionVirginia Commonwealth Univ
dc.contributor.institutionUniv Virginia
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:49:33Z
dc.date.available2016-01-24T13:49:33Z
dc.date.issued2008-02-01
dc.description.abstractObjective: Depression and anxiety are common in sickle cell disease (SCD) but relatively little is known about their impact on SCD adults. This study measured prevalence of depression and anxiety in SCD adults, and their effects on crisis and noncrisis pain, quality-of-life, opioid usage, and healthcare utilization. Methods: the Pain in Sickle Cell Epidemiology Study-is a prospective cohort study in 308 SCD adults. Baseline variables included demographics, genotype, laboratory data, health-related quality-of-life, depression, and anxiety. Subjects completed daily diaries for up to 6 months, reporting sickle cell pain intensity, distress, interference, whether they were in a sickle cell crisis, as well as health care and opioid utilization. Results: Two hundred thirty-two subjects who completed at least 1 month of diaries were studied; 27.6% were depressed and 6.5% had any anxiety disorder. Depressed subjects had pain on significantly more days than nondepressed subjects (mean pain days 71.1% versus 49.6%, p < .001). When in pain on noncrisis days, depressed subjects had higher mean pain, distress from pain, and interference from pain. Both depressed and anxious subjects bad poorer functioning on all eight SF-36 subscales, even after controlling for demographics, hemoglobin type, and pain. the anxious subjects had more pain, distress from pain, and interference from pain, both on noncrisis pain days and on crisis days, and used opioids more often. Conclusions: Depression and anxiety predicted more daily pain and poorer physical and mental quality-of-life in adults with SCD, and accounted for more of the variance in all domains of quality-of-life than hemoglobin type.en
dc.description.affiliationVirginia Commonwealth Univ, Dept Psychiat, Richmond, VA 23298 USA
dc.description.affiliationUniv Virginia, Dept Psychol, Charlottesville, VA 22903 USA
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent192-196
dc.identifierhttp://dx.doi.org/10.1097/PSY.0b013e31815ff5c5
dc.identifier.citationPsychosomatic Medicine. Philadelphia: Lippincott Williams & Wilkins, v. 70, n. 2, p. 192-196, 2008.
dc.identifier.doi10.1097/PSY.0b013e31815ff5c5
dc.identifier.issn0033-3174
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30437
dc.identifier.wosWOS:000253242800009
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofPsychosomatic Medicine
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectdepressionen
dc.subjectanxietyen
dc.subjectpainen
dc.subjectsickle cell diseaseen
dc.titleDepression and anxiety in adults with sickle cell disease: the PiSCES projecten
dc.typeinfo:eu-repo/semantics/article
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