Teriparatide (recombinant human parathyroid hormone 1-34) in postmenopausal women with osteoporosis: systematic review

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dc.contributor.authorTrevisani, Virginia Fernandes Moça [UNIFESP]
dc.contributor.authorRiera, Rachel
dc.contributor.authorImoto, Aline Mizusaki
dc.contributor.authorSaconato, Humberto
dc.contributor.authorAtallah, Álvaro Nagib [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Fed Rio Grande do Norte
dc.contributor.institutionBrazilian Cochrane Ctr
dc.contributor.institutionAPM
dc.date.accessioned2018-06-18T11:54:44Z
dc.date.available2018-06-18T11:54:44Z
dc.date.issued2008-09-04
dc.description.abstractCONTEXT AND OBJECTIVE: Osteoporosis is defined as a disease characterized by low bone mass and deterioration of the bone tissue microarchitecture. Teriparatide stimulates the formation and action of osteoblasts, which are responsible for bone formation, thus promoting bone tissue increase. The aim was to assess the effectiveness and safety of teriparatide for treating postmenopausal osteoporosis.METHODS: A systematic review was conducted using the Cochrane Collaboration methodology.RESULTS: 1) Teriparatide 20 mu g or 40 mu g versus placebo: there was a benefit from teriparatide, considering the following outcomes: reduction in the number of new vertebral and non-vertebral fractures, and increased whole-body, lumbar and femoral bone mineral density. 2) Teriparatide 40 mu g versus alendronate 10 mg/day for 14 months: there was no statistical difference regarding the incidence of new vertebral or non-vertebral fractures, although in the group that received teriparatide there was greater bone mineral density increase in the whole body, lumbar column and femur. 3) Estrogen plus teriparatide 25 mu g versus estrogen: there was a benefit, considering the following outcomes: reduction in the number of new vertebral fractures, and increased whole-body, lumbar and femoral bone mineral density after three years.CONCLUSIONS: When teriparatide is intermittently administered in low doses, it reduces the incidence of vertebral fractures (67%) and non-vertebral fractures (38%) and increases bone mineral density in the lumbar column and femur. There is a need for studies with longer observation in order to allow conclusions regarding the safety and duration of the therapeutic effects.en
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Div Emergency Med & Evidence Based Med, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Rio Grande do Norte, Discipline Propaedeut, BR-59072970 Natal, RN, Brazil
dc.description.affiliationBrazilian Cochrane Ctr, Sao Paulo, Brazil
dc.description.affiliationAPM, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Div Emergency Med & Evidence Based Med, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipDepartment of Science and Technology of the Brazilian Ministry of Health
dc.format.extent279-284
dc.identifierhttp://dx.doi.org/10.1590/S1516-31802008000500007
dc.identifier.citationSao Paulo Medical Journal. Sao Paulo: Associacao Paulista Medicina, v. 126, n. 5, p. 279-284, 2008.
dc.identifier.doi10.1590/S1516-31802008000500007
dc.identifier.fileS1516-31802008000500007.pdf
dc.identifier.issn1516-3180
dc.identifier.scieloS1516-31802008000500007
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/45544
dc.identifier.wosWOS:000262734600007
dc.language.isoeng
dc.publisherAssociacao Paulista Medicina
dc.relation.ispartofSao Paulo Medical Journal
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectOsteoporosisen
dc.subjectFractures, boneen
dc.subjectPostmenopauseen
dc.subjectTeriparatideen
dc.subjectReviewen
dc.titleTeriparatide (recombinant human parathyroid hormone 1-34) in postmenopausal women with osteoporosis: systematic reviewen
dc.title.alternativeTeriparatida (hormônio recombinante humano da paratireóide 1-34) para mulheres com osteoporose pós-menopausa: revisão sistemáticapt
dc.typeinfo:eu-repo/semantics/article
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