Serum endocan levels associated with hypertension and loss of renal function in pediatric patients after two years from renal transplant

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dc.contributor.authorde Souza, Livia Victorino [UNIFESP]
dc.contributor.authorOliveira, Vanessa [UNIFESP]
dc.contributor.authorLaurindo, Aline Oliveira [UNIFESP]
dc.contributor.authorHuarachi, DelmaRegina Gomes [UNIFESP]
dc.contributor.authorKoch Nogueira, Paulo Cesar [UNIFESP]
dc.contributor.authorFeltran, Luciana de Santis [UNIFESP]
dc.contributor.authorMedina-Pestana, Jose Osmar [UNIFESP]
dc.contributor.authorFranco, Andmaria do Carmo [UNIFESP]
dc.date.accessioned2019-01-21T10:29:32Z
dc.date.available2019-01-21T10:29:32Z
dc.date.issued2016
dc.description.abstractEndocan is an important biomarker of inflammation and endothelial dysfunction that increases in association with several chronic diseases. Few published data have described the role of endocan in pediatric renal transplant (RT) patients. We evaluated the endocan concentrations in 62 children who underwent renal transplantation and assessed their relationships with the patients' blood pressure and loss of renal function. The endocan levels were significantly elevated in the pediatric RT patients who had hypertension and a loss of renal function. We determined positive correlations between the endocan concentrations and the hemodynamic variables (systolic blood pressure: r = 0.416en
dc.description.abstractP = 0.001en
dc.description.abstractpulse pressure: r = 0.412en
dc.description.abstractP = 0.003). The endocan levels were inversely correlated with the estimated glomerular filtration rate (r = -0.388en
dc.description.abstractP = 0.003). An endocan cutoff concentration of 7.0 ng/mL identified pediatric RT patients who had hypertension and a loss of renal function with 100% sensitivity and 75% specificity. In conclusion, the endocan concentrations were significantly elevated in pediatric RT patients who had both hypertension and a loss of renal function. The correlations between the endocan levels and the hemodynamic variables and the markers of renal function strengthen the hypothesis that it is an important marker of cardiorenal risk.en
dc.description.affiliationNephrology Division, School of Medicine, Federal University of São Paulo, São Paulo, SP, Brazil
dc.description.affiliationPediatrics Department, School of Medicine, Federal University of São Paulo, São Paulo, SP, Brazil
dc.description.affiliationUnifespNephrology Division, School of Medicine, Federal University of São Paulo, São Paulo, SP, Brazil
dc.description.affiliationUnifespPediatrics Department, School of Medicine, Federal University of São Paulo, São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, Brazil) [2013/03139-0]
dc.description.sponsorshipCNPq (Conselho-Nacional de Desenvolvimento Cientifico e Tecnologico) [443248/2014-1]
dc.description.sponsorshipIDFAPESP: 2013/03139-0
dc.description.sponsorshipIDCNPq: 443248/2014-1
dc.identifierhttp://dx.doi.org/10.1155/2016/2180765
dc.identifier.citationInternational Journal Of Nephrology. London, 2016.
dc.identifier.doi10.1155/2016/2180765
dc.identifier.fileWOS000397868700001.pdf
dc.identifier.issn2090-214X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/49263
dc.identifier.wosWOS:000397868700001
dc.language.isoeng
dc.publisherDove Medical Press Ltd
dc.relation.ispartofInternational Journal Of Nephrology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChronic Kidney-Diseaseen
dc.subjectGlomerular-Filtration-Rateen
dc.subjectEndothelial Dysfunctionen
dc.subjectInflammatory Indicatoren
dc.subjectChildrenen
dc.subjectSurvivalen
dc.subjectAtherosclerosisen
dc.subjectRecipientsen
dc.subjectPressureen
dc.subjectMarkeren
dc.titleSerum endocan levels associated with hypertension and loss of renal function in pediatric patients after two years from renal transplanten
dc.typeinfo:eu-repo/semantics/article
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