Atopic dermatitis and vitamin D: facts and controversies

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dc.contributor.authorMesquita, Kleyton de Carvalho
dc.contributor.authorIgreja, Ana Carolina de Souza Machado
dc.contributor.authorCosta, Izelda Maria Carvalho [UNIFESP]
dc.contributor.institutionUniversidade de Brasília (UnB)
dc.contributor.institutionFed Dist Hlth State Dept SES DF
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:34:38Z
dc.date.available2016-01-24T14:34:38Z
dc.date.issued2013-11-01
dc.description.abstractPatients with atopic dermatitis have genetically determined risk factors that affect the barrier function of the skin and immune responses that interact with environmental factors. Clinically, this results in an intensely pruriginous and inflamed skin that allows the penetration of irritants and allergens and predisposes patients to colonization and infection by microorganisms. Among the various etiological factors responsible for the increased prevalence of atopic diseases over the past few decades, the role of vitamin D has been emphasized. As the pathogenesis of AD involves a complex interplay of epidermal barrier dysfunction and dysregulated immune response, and vitamin D is involved in both processes, it is reasonable to expect that vitamin D's status could be associated with atopic dermatitis' risk or severity. Such association is suggested by epidemiological and experimental data. in this review, we will discuss the evidence for and against this controversial relationship, emphasizing the possible etiopathogenic mechanisms involved.en
dc.description.affiliationUniv Brasilia UNB, Brasilia, DF, Brazil
dc.description.affiliationFed Dist Hlth State Dept SES DF, Brasilia, DF, Brazil
dc.description.affiliationUniv Brasilia HUB UNB, Brasilia Univ Hosp, Brasilia, DF, Brazil
dc.description.affiliationSão Paulo Fed Univ UNIFESP, Brasilia, DF, Brazil
dc.description.affiliationUnifespSão Paulo Fed Univ UNIFESP, EPM, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent945-953
dc.identifierhttp://dx.doi.org/10.1590/abd1806-4841.20132660
dc.identifier.citationAnais Brasileiros de Dermatologia. Rio de Janeiro Rj: Soc Brasileira Dermatologia, v. 88, n. 6, p. 945-953, 2013.
dc.identifier.doi10.1590/abd1806-4841.20132660
dc.identifier.fileS0365-05962013000600945.pdf
dc.identifier.issn0365-0596
dc.identifier.scieloS0365-05962013000600945
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36914
dc.identifier.wosWOS:000333045700012
dc.language.isoeng
dc.publisherSoc Brasileira Dermatologia
dc.relation.ispartofAnais Brasileiros de Dermatologia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDefensinsen
dc.subjectDermatitisen
dc.subjectatopicen
dc.subjectVitamin Den
dc.subjectVitamin D Deficiencyen
dc.titleAtopic dermatitis and vitamin D: facts and controversiesen
dc.typeinfo:eu-repo/semantics/article
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