Nutritional status of hemodialysis patients with secondary hyperparathyroidism

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dc.contributor.authorRezende, Luciana Trindade Teixeira [UNIFESP]
dc.contributor.authorCuppari, Lilian [UNIFESP]
dc.contributor.authorCarvalho, A.b. [UNIFESP]
dc.contributor.authorCanziani, Maria Eugênia Fernandes [UNIFESP]
dc.contributor.authorManfredi, Sílvia Regina [UNIFESP]
dc.contributor.authorCendoroglo Neto, Miguel [UNIFESP]
dc.contributor.authorSigulem, Dirce Maria [UNIFESP]
dc.contributor.authorDraibe, Sergio Antonio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:25:08Z
dc.date.available2015-06-14T13:25:08Z
dc.date.issued2000-11-01
dc.description.abstractThe repercussions of secondary hyperparathyroidism on the nutritional status of chronic renal failure patients have not been well established. Therefore, the aim of this study was to compare the nutritional indices of hemodialysis patients with and without secondary hyperparathyroidism. Sixteen hemodialysis patients with serum parathyroid hormone (PTH) levels higher than 420 pg/ml (hyperparathyroidism group) were matched for gender, age and length of dialysis treatment to 16 patients with serum PTH between 64 and 290 pg/ml (control group). The following parameters were assessed: anthropometric indices (body mass index, skinfold thickness, midarm muscle circumference and body fat), 4-day food diaries, protein catabolic rate, biochemical indices (blood urea nitrogen, serum creatinine, albumin, ionized calcium, inorganic phosphorus, serum alkaline phosphatase, PTH, pH and HCO3) and dialysis efficiency. We did not observe differences in the anthropometric indices between the two groups. Only calcium intake was significantly different between groups (307.9 mg/day for the hyperparathyroidism group vs 475.8 mg/day for the control group). Protein catabolic rate tended to be higher in the hyperparathyroidism group compared to the control group (1.3 vs 0.9 g kg-1 day-1; P = 0.08). Except for blood urea nitrogen (86.4 vs 75.7 mg/dl), alkaline phosphatase (175 vs 65 U/l) and PTH (898 vs 155 pg/ml), no other differences were found between groups in the biochemical indices studied. PTH was directly correlated with protein catabolic rate (r = 0.61; P<0.05) and length of dialysis (r = 0.53; P<0.05) only in the hyperparathyroidism group. Considering the indices used, we could not demonstrate the deleterious effect of high PTH levels on the nutritional status of hemodialysis patients. Indirect evidence, however, suggests an action of PTH on protein metabolism.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Departamento de Medicina Disciplina de Nefrologia
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Departamento de Pediatria
dc.description.affiliationUnifespUNIFESP, Depto. de Medicina Disciplina de Nefrologia
dc.description.affiliationUnifespUNIFESP, Depto. de Pediatria
dc.description.sourceSciELO
dc.format.extent1305-1311
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2000001100007
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 33, n. 11, p. 1305-1311, 2000.
dc.identifier.doi10.1590/S0100-879X2000001100007
dc.identifier.fileS0100-879X2000001100007.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2000001100007
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/1049
dc.identifier.wosWOS:000165487100007
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectnutritional assessmenten
dc.subjectparathormoneen
dc.subjectchronic renal failureen
dc.subjectsecondary hyperparathyroidismen
dc.titleNutritional status of hemodialysis patients with secondary hyperparathyroidismen
dc.typeinfo:eu-repo/semantics/article
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