Gastric secretion elicited by conditioning in rats

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dc.contributor.authorCaboclo, Jose Liberato Ferreira
dc.contributor.authorCury, Francico de Assis
dc.contributor.authorBorin, Aldenis Albanese
dc.contributor.authorCaboclo, Luis Otavio Sales Ferreira [UNIFESP]
dc.contributor.authorRibeiro, Maria Fernanda Sales Caboclo
dc.contributor.authorFreitas, Pedro Jose de
dc.contributor.authorAndersson, Sven
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionSt Vicent Hosp
dc.contributor.institutionKarolinska Inst
dc.date.accessioned2016-01-24T13:52:05Z
dc.date.available2016-01-24T13:52:05Z
dc.date.issued2009-01-01
dc.description.abstractObjective. To investigate whether interdigestive gastric acid secretion can be controlled by a possible memory-related cortical mechanism. Material and methods. To evaluate gastric secretion in rats, we used a methodology that allows gastric juice collection in rats in their habitual conditions (without any restraining) by pairing sound as the conditioning stimulus (CS) and food as the unconditioning stimulus (US). the levels of gastric acid secretion under basal conditions and under sound stimulation were recorded and the circulating gastrin levels determined. Results. When the gastric juice was collected in the course of the conditioning procedure, the results showed that under noise stimulation a significant increase in gastric acid secretion occurred after 10 days of conditioning (p0.01). the significance was definitively demonstrated after 13 days of conditioning (p0.001). Basal secretions of the conditioned rats reached a significant level after 16 days of conditioning. the levels of noise-stimulated gastric acid secretion were the highest so far described in physiological experiments carried out in rats and there were no significant increases in the circulating gastrin levels. Conclusions. the results point to the important role played by cortical structures in the control of interdigestive gastric acid secretion in rats. If this mechanism is also present in humans, it may be involved in diseases caused by inappropriate gastric acid secretion during the interprandial periods.en
dc.description.affiliationMed Sch Sao Jose do Rio Preto FAMERP, Dept Surg, Sao Jose Do Rio Preto, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Sch Med, São Paulo, SP, Brazil
dc.description.affiliationSt Vicent Hosp, Curitiba, Parana, Brazil
dc.description.affiliationMed Sch Sao Jose do Rio Preto FAMERP, Expt Surg Lab, Sao Jose Do Rio Preto, SP, Brazil
dc.description.affiliationKarolinska Inst, Dept Pharmacol, S-10401 Stockholm, Sweden
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Sch Med, São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent672-679
dc.identifierhttp://dx.doi.org/10.1080/00365520802588083
dc.identifier.citationScandinavian Journal of Gastroenterology. Oslo: Taylor & Francis As, v. 44, n. 6, p. 672-679, 2009.
dc.identifier.doi10.1080/00365520802588083
dc.identifier.issn0036-5521
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31188
dc.identifier.wosWOS:000266199200004
dc.language.isoeng
dc.publisherTaylor & Francis As
dc.relation.ispartofScandinavian Journal of Gastroenterology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dc.subjectConditioningen
dc.subjectemotional factors in peptic diseaseen
dc.subjectetiopathogeny of peptic ulceren
dc.subjectgastric secretion mechanismsen
dc.subjectgastrin trophic effecten
dc.subjectgastrin vegal releaseen
dc.subjectlong-term potentiationen
dc.subjectPACUPen
dc.subjectparietal cell hyperplasiaen
dc.titleGastric secretion elicited by conditioning in ratsen
dc.typeinfo:eu-repo/semantics/article
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