Effects of sodium nitroprusside in the prevention of schizophrenia-like symptoms induced by ketamine - A translational double-blind study

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dc.citation.issue6
dc.citation.volume44
dc.contributor.authorRezende, Tatiana M. N.
dc.contributor.authorMaia-de-Oliveira, Joao Paulo
dc.contributor.authorKandratavicius, Ludmyla
dc.contributor.authorMachado-de-Sousa, Joao Paulo
dc.contributor.authorAbrao, Joao
dc.contributor.authorPrado, Daniel Almeida
dc.contributor.authorBressan, Rodrigo A. [UNIFESP]
dc.contributor.authorLacerda, Acioly L. T. [UNIFESP]
dc.contributor.authorZuardi, Antonio W.
dc.contributor.authorBaker, Glen B.
dc.contributor.authorDursun, Serdar M.
dc.contributor.authorHallak, Jaime E. C.
dc.coverageSao Paulo
dc.date.accessioned2020-09-01T13:21:19Z
dc.date.available2020-09-01T13:21:19Z
dc.date.issued2017
dc.description.abstractBackground: Recent evidence has shown improvements in schizophrenia symptoms after the infusion of sodium nitroprusside (SNP), a nitric oxide (NO) donor. In the rat model of schizophrenia using ketamine injection, pretreatment with SNP seems to prevent behavioral changes associated with positive symptoms for up to one week. Objective: We investigated whether SNP would have preventative effects on psychogenic symptoms induced by ketamine in healthy subjects. Methods: Healthy subjects (N = 38) were assigned to distinct groups that received SNP in different doses (0.15, 0.25, and 0.5 mcg/kg/min). First, participants received an infusion of SNP or placebo over 75 minutes. After 10 minutes, they were injected for 1 minute with a bolus of 0.26 mg/kg of ketamine and a maintenance dose was started 5 minutes later, with 0.25 mg/kg/h of ketamine for 50 minutes. Results: Ketamine-induced psychopathological alterations induced were reduced by SNP, as assessed with the Brief Psychological Rating Scale. Scores in the objective subscale of the Clinician-Administered Dissociative States Scale were also lower in SNP sessions compared to placebo. SNP had protective effects against deterioration in facial emotion and identity recognition tasks induced by ketamine. Discussion: Our findings support the view that SNP has preventative properties against psychotic manifestations.en
dc.description.affiliationUniv Sao Paulo, Fac Med Ribeirao Preto, Dept Neurosci & Behav, Ribeirao Preto, SP, Brazil
dc.description.affiliationNatl Inst Sci & Technol Translat Med INCT TM, Fortaleza, Ceara, Brazil
dc.description.affiliationUniv Fed Rio Grande do Norte, Dept Clin Med, Natal, RN, Brazil
dc.description.affiliationFed Univ Sao Paulo Unifesp, Dept Psychiat, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Alberta, Dept Psychiat, Neurochem Res Unit, Edmonton, AB, Canada
dc.description.affiliationUnifespFed Univ Sao Paulo Unifesp, Dept Psychiat, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent149-153
dc.identifierhttp://dx.doi.org/10.1590/0101-60830000000141
dc.identifier.citationArchives Of Clinical Psychiatry. Sao Paulo, v. 44, n. 6, p. 149-153, 2017.
dc.identifier.doi10.1590/0101-60830000000141
dc.identifier.fileS0101-60832017000600149.pdf
dc.identifier.issn0101-6083
dc.identifier.scieloS0101-60832017000600149
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58201
dc.identifier.wosWOS:000419784600003
dc.language.isoeng
dc.publisherUniv Sao Paulo, Inst Psiquiatria
dc.relation.ispartofArchives Of Clinical Psychiatry
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNitric oxideen
dc.subjectsodium nitroprussideen
dc.subjectketamineen
dc.subjectschizophreniaen
dc.subjectpsychosisen
dc.titleEffects of sodium nitroprusside in the prevention of schizophrenia-like symptoms induced by ketamine - A translational double-blind studyen
dc.typeinfo:eu-repo/semantics/article
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