Olfactory Heterogeneity in LRRK2 Related Parkinsonism

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dc.contributor.authorSilveira-Moriyama, Laura
dc.contributor.authorMunhoz, Renato Pupi
dc.contributor.authorCarvalho, Margarete de J.
dc.contributor.authorRaskin, Salmo
dc.contributor.authorRogaeva, Ekaterina
dc.contributor.authorAguiar, Patricia de C.
dc.contributor.authorBressan, Rodrigo A. [UNIFESP]
dc.contributor.authorFelicio, Andre C. [UNIFESP]
dc.contributor.authorBarsottini, Orlando G. P. [UNIFESP]
dc.contributor.authorAndrade, Luiz Augusto Franco de [UNIFESP]
dc.contributor.authorChien, Hsin F.
dc.contributor.authorBonifati, Vincenzo
dc.contributor.authorBarbosa, Egberto R.
dc.contributor.authorTeive, Helio A.
dc.contributor.authorLees, Andrew J.
dc.contributor.institutionUCL
dc.contributor.institutionUniv Fed Parana
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Toronto
dc.contributor.institutionHosp Israelita Albert Einstein
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionErasmus MC
dc.date.accessioned2016-01-24T14:05:49Z
dc.date.available2016-01-24T14:05:49Z
dc.date.issued2010-12-15
dc.description.abstractLRRK2 mutations can cause familial and sporadic Parkinson's disease (PD) with Lewy-body pathology at post-mortem. Studies of olfaction in LRRK2 are sparse and incongruent. We applied a previously validated translation of the 16 item smell identification test from Sniffin' Sticks (SS-16) to 14 parkinsonian carriers of heterozygous G2019S LRRK2 mutation and compared with 106 PD patients and 118 healthy controls. the mean SS-16 score in LRRK2 was higher than in PD (p < 0.001, 95% CI for beta = -4.7 to -1.7) and lower than in controls (p = 0.007, 95% CI for beta = +0.6 to +3.6). in the LRRK2 group, subjects with low scores had significantly more dyskinesia. They also had younger age of onset, longer disease duration, and reported less frequently a family history of PD, but none of these other differences reached significance. Odor identification is diminished in LRRK2 parkinsonism but not to the same extent as in idiopathic PD. (C) 2010 Movement Disorder Societyen
dc.description.affiliationUCL, Inst Neurol, Reta Lila Weston Inst Neurol Studies, London WC1N 1PJ, England
dc.description.affiliationUniv Fed Parana, Hosp Clin, Dept Internal Med, Neurol Serv,Movement Disorders Unit, Curitiba, Parana, Brazil
dc.description.affiliationUniv São Paulo, Sch Med, Dept Neurol, São Paulo, Brazil
dc.description.affiliationUniv Toronto, Ctr Res Neurodegenerat Dis, Toronto, ON, Canada
dc.description.affiliationHosp Israelita Albert Einstein, Inst Israelita Ensino & Pesquisa Albert Einstein, Inst Cerebro, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Universidade Federal de São Paulo, LiNC, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Neurol & Neurosurg, São Paulo, Brazil
dc.description.affiliationErasmus MC, Dept Clin Genet, Rotterdam, Netherlands
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Universidade Federal de São Paulo, LiNC, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Neurol & Neurosurg, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipReta Lila Weston Trust for Medical Research and Foundation Philantropique Edmond Safra
dc.format.extent2879-2883
dc.identifierhttp://dx.doi.org/10.1002/mds.23325
dc.identifier.citationMovement Disorders. Hoboken: Wiley-liss, v. 25, n. 16, p. 2879-2883, 2010.
dc.identifier.doi10.1002/mds.23325
dc.identifier.issn0885-3185
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33170
dc.identifier.wosWOS:000285979200035
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofMovement Disorders
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectolfactionen
dc.subjectsmellen
dc.subjectLRRK2en
dc.subjectPARK8en
dc.subjectparkinsonismen
dc.titleOlfactory Heterogeneity in LRRK2 Related Parkinsonismen
dc.typeinfo:eu-repo/semantics/article
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