Epidemiology of fungal infections in liver transplant recipients: a six-year study of a large Brazilian liver transplantation centre

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dc.contributor.authorZicker, Michelle [UNIFESP]
dc.contributor.authorColombo, Arnaldo Lopes [UNIFESP]
dc.contributor.authorFerraz-neto, Ben-hur
dc.contributor.authorCamargo, Luis Fernando Aranha [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHospital Israelita Albert Einstein
dc.date.accessioned2015-06-14T13:43:04Z
dc.date.available2015-06-14T13:43:04Z
dc.date.issued2011-05-01
dc.description.abstractLiver transplant seems to be an effective option to prolong survival in patients with end-stage liver disease, although it still can be followed by serious complications. Invasive fungal infections (ifi) are related to high rates of morbidity and mortality. The epidemiology of fungal infections in Brazilian liver transplant recipients is unknown. The aim of this observational and retrospective study was to determine the incidence and epidemiology of fungal infections in all patients who underwent liver transplantation at Albert Einstein Israeli Hospital between 2002-2007. A total of 596 liver transplants were performed in 540 patients. Overall, 77 fungal infections occurred in 68 (13%) patients. Among the 77 fungal infections, there were 40 IFI that occurred in 37 patients (7%). Candida and Aspergillus species were the most common etiologic agents. Candida species accounted for 82% of all fungal infections and for 67% of all IFI, while Aspergillus species accounted for 9% of all fungal infections and for 17% of all IFI. Non-albicans Candida species were the predominant Candida isolates. Invasive aspergillosis tended to occur earlier in the post-transplant period. These findings can contribute to improve antifungal prophylaxis and therapy practices in Brazilian centres.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationHospital Israelita Albert Einstein
dc.description.affiliationUnifespUNIFESP, EPM, Sao Paulo, Brazil
dc.description.sourceSciELO
dc.format.extent339-345
dc.identifierhttp://dx.doi.org/10.1590/S0074-02762011000300014
dc.identifier.citationMemórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 106, n. 3, p. 339-345, 2011.
dc.identifier.doi10.1590/S0074-02762011000300014
dc.identifier.fileS0074-02762011000300014.pdf
dc.identifier.issn0074-0276
dc.identifier.scieloS0074-02762011000300014
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/6449
dc.identifier.wosWOS:000291319200014
dc.language.isoeng
dc.publisherInstituto Oswaldo Cruz, Ministério da Saúde
dc.relation.ispartofMemórias do Instituto Oswaldo Cruz
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectliver transplantationen
dc.subjectmycosesen
dc.subjectepidemiologyen
dc.titleEpidemiology of fungal infections in liver transplant recipients: a six-year study of a large Brazilian liver transplantation centreen
dc.typeinfo:eu-repo/semantics/article
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