Lower follicular fluid vitamin D concentration is related to a higher number of large ovarian follicles

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dc.citation.issue3
dc.citation.volume36
dc.contributor.authorAntunes, Roberto A.
dc.contributor.authorMancebo, Ana C. A.
dc.contributor.authorReginatto, Mila W.
dc.contributor.authorDeriquehem, Vitor A. S.
dc.contributor.authorAreas, Patricia
dc.contributor.authorBloise, Enrrico
dc.contributor.authorChiamolera, Maria I. [UNIFESP]
dc.contributor.authorRibeiro, Gabriel C. M.
dc.contributor.authorCarvalho, Alysson R. S.
dc.contributor.authorSouza, Maria C. B.
dc.contributor.authorOrtiga-Carvalho, Tania M.
dc.coverageOxford
dc.date.accessioned2020-07-08T13:09:31Z
dc.date.available2020-07-08T13:09:31Z
dc.date.issued2018
dc.description.abstractVitamin D receptor-knockout mice fail to produce mature oocytes, indicating vitamin D is crucial for folliculogenesis in mice. However, the actions of vitamin D during folliculogenesis remain unknown. This prospective study aimed to assess whether follicular fluid (FF) vitamin D (25OHD3) concentrations are related to specific responses to ovarian stimulation. Women undergoing ovarian stimulation for IVF participated in the study. FF 25OHD3 concentrations were assessed in the first follicle aspirate on oocyte retrieval day. Oestradiol and progesterone concentrations were assessed on the trigger day. K-means grouping analysis showed that 25OHD3 FF concentrations clustered into a higher and lower group (mean +/- SEM 17.4 +/- 6.61 ng/ml and 35.5 +/- 7.17 ng/ml, respectively, P < 0.001). The clusters were analysed according to the oestradiol and progesterone concentrations, follicle number and size and resulting oocyte number and maturity. The FF 25OHD3 concentrations were no different among the infertility diagnoses. The lower 25OHD3 group had more follicles (>= 16.0 mm, P = 0.009) and higher serum oestradiol concentrations (P < 0.03) on the day of HCG administration. In this study, lower follicular 25OHD3 concentrations predicted a better response to ovarian stimulation shown by a greater production of larger follicles and higher serum oestradiol concentrations. (c) 2017 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.en
dc.description.affiliationFertipraxis Ctr Reprod Humana, Rio De Janeiro, Brazil
dc.description.affiliationCtr Ciencias Saude, Inst Biofis Carlos Chagas Filho, UFRJ Edificio,Bloco GAv Charlos Chagas Filho S-N, Rio De Janeiro, RJ, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, Maternidade Escola, Rio de Janeiro, Brazil
dc.description.affiliationUniv Fed Minas Gerais, Dept Morfol, Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Fed Sao Paulo, UNIFESP, Escol Paulista Med, Dept Med, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, UNIFESP, Escol Paulista Med, Dept Med, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro, Rio de Janeiro Research Foundation (FAPERJ)
dc.description.sponsorshipBrazilian Council for Scientific and Technological Development (CNPq)
dc.description.sponsorshipCoordination for the Improvement of Higher Education Personnel (CAPES )
dc.description.sponsorshipIDFAPERJ : E-26/112.063/2012, E-26/203.190/2015]
dc.description.sponsorshipIDCNPq :303734/2012-4, 473828/2012-0, 402343/2012-3]
dc.description.sponsorshipIDCAPES
dc.format.extent277-284
dc.identifierhttp://dx.doi.org/10.1016/j.rbmo.2017.12.010
dc.identifier.citationReproductive Biomedicine Online. Oxford, v. 36, n. 3, p. 277-284, 2018.
dc.identifier.doi10.1016/j.rbmo.2017.12.010
dc.identifier.issn1472-6483
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54057
dc.identifier.wosWOS:000426313200005
dc.language.isoeng
dc.publisherElsevier Sci Ltd
dc.relation.ispartofReproductive Biomedicine Online
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectCalcitriolen
dc.subjectFertilityen
dc.subjectFollicular fluiden
dc.subjectIVFen
dc.subjectOestradiolen
dc.subjectOvarian stimulationen
dc.titleLower follicular fluid vitamin D concentration is related to a higher number of large ovarian folliclesen
dc.typeinfo:eu-repo/semantics/article
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