A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: management strategies and economic impact

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dc.contributor.authorJensen, S. B.
dc.contributor.authorPedersen, A. M. L.
dc.contributor.authorVissink, A.
dc.contributor.authorAndersen, E.
dc.contributor.authorBrown, C. G.
dc.contributor.authorDavies, A. N.
dc.contributor.authorDutilh, J.
dc.contributor.authorFulton, J. S.
dc.contributor.authorJankovic, L.
dc.contributor.authorLopes, N. N. F. [UNIFESP]
dc.contributor.authorMello, A. L. S. [UNIFESP]
dc.contributor.authorMuniz, L. V.
dc.contributor.authorMurdoch-Kinch, C. A.
dc.contributor.authorNair, R. G.
dc.contributor.authorNapenas, J. J.
dc.contributor.authorNogueira-Rodrigues, A.
dc.contributor.authorSaunders, D.
dc.contributor.authorStirling, B.
dc.contributor.authorvon Bueltzingsloewen, I.
dc.contributor.authorWeikel, D. S.
dc.contributor.authorElting, L. S.
dc.contributor.authorSpijkervet, F. K. L.
dc.contributor.authorBrennan, M. T.
dc.contributor.authorMASCC ISOO
dc.contributor.institutionUniv Copenhagen
dc.contributor.institutionUniv Groningen
dc.contributor.institutionHerlev Univ Hosp
dc.contributor.institutionUniv Delaware
dc.contributor.institutionRoyal Marsden Hosp
dc.contributor.institutionDutilh Inst Reabilitacao Facial Oral
dc.contributor.institutionIndiana Univ
dc.contributor.institutionUniv Belgrade
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHosp Cancer Ctr Oeste Minas Gerais
dc.contributor.institutionUniv Michigan
dc.contributor.institutionGriffith Univ
dc.contributor.institutionCarolinas Med Ctr
dc.contributor.institutionHop Reg Sudbury Reg Hosp
dc.contributor.institutionUniv Gothenburg
dc.contributor.institutionUniv Maryland
dc.contributor.institutionGreenebaum Canc Ctr
dc.contributor.institutionUniv Texas MD Anderson Canc Ctr
dc.date.accessioned2016-01-24T14:05:16Z
dc.date.available2016-01-24T14:05:16Z
dc.date.issued2010-08-01
dc.description.abstractThis systematic review aimed to assess the literature for management strategies and economic impact of salivary gland hypofunction and xerostomia induced by cancer therapies and to determine the quality of evidence-based management recommendations.The electronic databases of MEDLINE/PubMed and EMBASE were searched for articles published in English since the 1989 NIH Development Consensus Conference on the Oral Complications of Cancer Therapies until 2008 inclusive. for each article, two independent reviewers extracted information regarding study design, study population, interventions, outcome measures, results, and conclusions.Seventy-two interventional studies met the inclusion criteria. in addition, 49 intensity-modulated radiation therapy (IMRT) studies were included as a management strategy aiming for less salivary gland damage. Management guideline recommendations were drawn up for IMRT, amifostine, muscarinic agonist stimulation, oral mucosal lubricants, acupuncture, and submandibular gland transfer.There is evidence that salivary gland hypofunction and xerostomia induced by cancer therapies can be prevented or symptoms be minimized to some degree, depending on the type of cancer treatment. Management guideline recommendations are provided for IMRT, amifostine, muscarinic agonist stimulation, oral mucosal lubricants, acupuncture, and submandibular gland transfer. Fields of sparse literature identified included effects of gustatory and masticatory stimulation, specific oral mucosal lubricant formulas, submandibular gland transfer, acupuncture, hyperbaric oxygen treatment, management strategies in pediatric cancer populations, and the economic consequences of salivary gland hypofunction and xerostomia.en
dc.description.affiliationUniv Copenhagen, Dept Oral Med Clin Oral Physiol Oral Pathol & Ana, Inst Odontol, Fac Hlth Sci, DK-2200 Copenhagen, Denmark
dc.description.affiliationUniv Groningen, Dept Oral & Maxillofacial Surg, Univ Med Ctr Groningen, NL-9700 RB Groningen, Netherlands
dc.description.affiliationHerlev Univ Hosp, Dept Oncol, DK-2730 Herlev, Denmark
dc.description.affiliationUniv Delaware, Sch Nursing, Coll Hlth Sci, Newark, de 19716 USA
dc.description.affiliationRoyal Marsden Hosp, Dept Palliat Med, Sutton SM2 5P5, Surrey, England
dc.description.affiliationDutilh Inst Reabilitacao Facial Oral, Taquaral, Brazil
dc.description.affiliationIndiana Univ, Sch Nursing, Dept Adult Hlth, Indianapolis, in 46202 USA
dc.description.affiliationUniv Belgrade, Clin Periodontol & Oral Med, Fac Stomatol, Belgrade 11000, Serbia
dc.description.affiliationUniversidade Federal de São Paulo, Serv Oral Med, IOP, Pediat Oncol Inst GRAACC, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Endocrinol, São Paulo, Brazil
dc.description.affiliationHosp Cancer Ctr Oeste Minas Gerais, IPOM, Dept Odontol,Inst Pesquisas Oncol Minas Gerais, Associacao Combate Cancer Ctr Oeste Minas Gerais, Minas Gerais, Brazil
dc.description.affiliationUniv Michigan, Dept Oral & Maxillofacial Surg, Hosp Dent, Sch Dent, Ann Arbor, MI 48109 USA
dc.description.affiliationGriffith Univ, Ctr Med & Oral Hlth, Gold Coast, Qld 4222, Australia
dc.description.affiliationCarolinas Med Ctr, Dept Oral Med, Charlotte, NC 28232 USA
dc.description.affiliationHosp Cancer Ctr Oeste Minas Gerais, Dept Oncol & Res, Associacao Combate Cancer Ctr Oeste Minas Gerais, Inst Pesquisas Oncol Minas Gerais,IPOM, Minas Gerais, Brazil
dc.description.affiliationHop Reg Sudbury Reg Hosp, Dept Dent, Sudbury Reg Hosp Canc Program, Sudbury, ON P3E 5J1, Canada
dc.description.affiliationUniv Gothenburg, Dept Oral Immunol & Oral Med, Inst Odontol, Sahlgrenska Acad, S-41390 Gothenburg, Sweden
dc.description.affiliationUniv Maryland, Sch Dent, Dept Pathol & Diagnost Sci, Baltimore, MD 21201 USA
dc.description.affiliationGreenebaum Canc Ctr, Baltimore, MD 21201 USA
dc.description.affiliationUniv Texas MD Anderson Canc Ctr, Dept Biostat, Houston, TX 77030 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Serv Oral Med, IOP, Pediat Oncol Inst GRAACC, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Endocrinol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1061-1079
dc.identifierhttp://dx.doi.org/10.1007/s00520-010-0837-6
dc.identifier.citationSupportive Care in Cancer. New York: Springer, v. 18, n. 8, p. 1061-1079, 2010.
dc.identifier.doi10.1007/s00520-010-0837-6
dc.identifier.issn0941-4355
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32772
dc.identifier.wosWOS:000280599200018
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofSupportive Care in Cancer
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectCancer therapyen
dc.subjectSalivary gland hypofunctionen
dc.subjectXerostomiaen
dc.subjectManagement strategiesen
dc.subjectEconomic impacten
dc.titleA systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: management strategies and economic impacten
dc.typeinfo:eu-repo/semantics/article
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