Understanding posttraumatic stress disorder through fear conditioning, extinction and reconsolidation

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dc.citation.volume71
dc.contributor.authorCareaga, Mariella Bodemeier Loayza [UNIFESP]
dc.contributor.authorGirardi, Carlos Eduardo Neves [UNIFESP]
dc.contributor.authorSuchecki, Deborah [UNIFESP]
dc.coverageOxford
dc.date.accessioned2020-07-31T12:47:10Z
dc.date.available2020-07-31T12:47:10Z
dc.date.issued2016
dc.description.abstractCareaga MBL, Girardi CEN, Suchecki D. Understanding posttraumatic stress disorder through fear conditioning, extinction and reconsolidation. NEUROSCI BIOBEHAV REV - Posttraumatic stress disorder (PTSD) is a psychopathology characterized by exacerbation of fear response. A dysregulated fear response may be explained by dysfunctional learning and memory, a hypothesis that was proposed decades ago. A key component of PTSD is fear conditioning and the study of this phenomenon in laboratory has expanded the understanding of the underlying neurobiological changes in PTSD. Furthermore, traumatic memories are strongly present even years after the trauma and maintenance of this memory is usually related to behavioral and physiological maladaptive responses. Persistence of traumatic memory may be explained by a dysregulation of two memory processes: extinction and reconsolidation. The former may explain the over-expression of fear responses as an imbalance between traumatic and extinction memory. The latter, in turn, explains the maintenance of fear responses as a result of enhancing trauma-related memories. Thus, this review will discuss the importance of fear conditioning for the establishment of PTSD and how failure in extinction or abnormal reconsolidation may contribute to the maintenance of fear response overtime. (C) 2016 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Psicobiol, Rua Napoleao Barros 925, BR-04024002 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespDepartamento de Psicobiologia – Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent48-57
dc.identifierhttp://dx.doi.org/10.1016/j.neubiorev.2016.08.023
dc.identifier.citationNeuroscience And Biobehavioral Reviews. Oxford, v. 71, p. 48-57, 2016.
dc.identifier.doi10.1016/j.neubiorev.2016.08.023
dc.identifier.issn0149-7634
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56631
dc.identifier.wosWOS:000390502100004
dc.language.isoeng
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofNeuroscience And Biobehavioral Reviews
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectFear conditioningen
dc.subjectExtinctionen
dc.subjectReconsolidationen
dc.subjectPTSDen
dc.subjectMemory persistenceen
dc.titleUnderstanding posttraumatic stress disorder through fear conditioning, extinction and reconsolidationen
dc.typeinfo:eu-repo/semantics/article
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